783342-35-8Relevant articles and documents
Estrogen receptor ligands. Part 10: Chromanes: Old scaffolds for new SERAMs
Tan, Qiang,Blizzard, Timothy A.,Morgan II, Jerry D.,Birzin, Elizabeth T.,Chan, Wanda,Yang, Yi Tien,Pai, Lee-Yuh,Hayes, Edward C.,Dasilva, Carolyn A.,Warrier, Sudha,Yudkovitz, Joel,Wilkinson, Hilary A.,Sharma, Nandini,Fitzgerald, Paula M.D.,Li, Susan,Colwell, Lawrence,Fisher, John E.,Adamski, Sharon,Reszka, Alfred A.,Kimmel, Donald,Dininno, Frank,Rohrer, Susan P.,Freedman, Leonard P.,Schaeffer, James M.,Hammond, Milton L.
, p. 1675 - 1681 (2007/10/03)
The discovery, synthesis, and SAR of chromanes as ERα subtype selective ligands are described. X-ray studies revealed that the origin of the ERα-selectivity resulted from a C-4 trans methyl substitution to the cis-2,3-diphenyl-chromane platform. Selected