- Synthesis and biological evaluation of the salicylamide and salicylic acid derivatives as anti-estrogen agents
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Alkylphenols have xenoestrogenic activity, which mimic the action of physiological estrogens and these mimicking activities are mainly mediated by nongenomic pathway. Nongenomic pathway plays a pivotal role in breast, endometrial and ovarian cancers' growth and development. In this study, various alkylphenol derivatives were prepared and screened for their anti-uterotrophic and uterotrophic activity. Among these compounds, 2-hydroxy-5-nonanoylbenzamide (compound 1b) showed 93.99% inhibitory activity in the anti-uterotrophic test performed, and was found inactive in the uterotrophic activity test. Moreover, all test compounds were examined for the effect on uterine histopathological changes, and plasma 17β-estradiol (E2) level. Compound 1b was also tested for in vitro anti-cancer activity against ER+, human breast cancer cell line MCF-7, and it reduced cell viability to 74.01% at 50 nM concentration.
- Duendar, Yasemin,Oezatik, Yasemin,Oezatik, Orhan,Ergin, Volkan,Oenkol, Tijen,Menevse, Adnan,Erol, Kevser,Sahin, M. Fethi
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experimental part
p. 481 - 490
(2012/09/25)
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- Synthesis of Lipophilic Crown Ethers with Pendant Carboxylic Acid Groups
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Synthetic routes to thirteen highly lipophilic crown ether carboxylic acids are described.Seven contain 12-15-membered crown ether units with four ring oxygens and are designed for lithium ion complexation.Three others possess large ring 24-crown-8,27-cro
- Czech, Bronislaw P.,Czech, Anna,Son, Byungki,Lee, Han Koo,Bartsch, Richard A.
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p. 465 - 471
(2007/10/02)
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- Novel salicylanilides and microbiocidal compositions and uses thereof
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The composition comprises certain 5-acylsalicylanilides and more particularly comprises the compounds encompassed by the following generic formula: STR1 Where Z is a substituted phenyl ring of from 6 to 30 carbon atoms including substituents, R is a subst
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