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784210-87-3

RGB-286638 is a potent small molecule inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase, a key enzyme involved in the replication of the virus. It possesses strong antiviral activity against HIV-1 by binding to the integrase enzyme and preventing it from catalyzing the integration of viral DNA into the host genome, thereby inhibiting the virus from replicating and spreading. RGB-286638 has demonstrated good pharmacokinetic properties in animal models and is being investigated as a potential therapeutic agent for the treatment of HIV-1 infection, holding promise for the development of new antiretroviral drugs.

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  • 784210-87-3 Structure

  • Basic information

    1. Product Name: RGB-286638
    2. Synonyms: RGB-286638;N-[1,4-Dihydro-3-[4-[[4-(2-methoxyethyl)-1-piperazinyl]methyl]phenyl]-4-oxoindeno[1,2-c]pyrazol-5-yl]-N'-4-morpholinylurea hydrochloride
    3. CAS NO:784210-87-3
    4. Molecular Formula: C29H37Cl2N7O4
    5. Molecular Weight: 618.55458
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 784210-87-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: RGB-286638(CAS DataBase Reference)
    10. NIST Chemistry Reference: RGB-286638(784210-87-3)
    11. EPA Substance Registry System: RGB-286638(784210-87-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 784210-87-3(Hazardous Substances Data)

784210-87-3 Usage

Uses

Used in Pharmaceutical Industry:
RGB-286638 is used as an antiviral agent for the treatment of HIV-1 infection. Its strong inhibitory effect on the integrase enzyme makes it a promising candidate for the development of new antiretroviral drugs, offering a potential therapeutic solution for patients suffering from HIV-1.
Used in Research and Development:
RGB-286638 is used as a research tool in the study of HIV-1 integrase and its role in the replication of the virus. Its potent inhibitory activity allows researchers to investigate the mechanisms of action and potential resistance to this compound, contributing to the advancement of knowledge in the field of HIV-1 research and drug development.

Check Digit Verification of cas no

The CAS Registry Mumber 784210-87-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,8,4,2,1 and 0 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 784210-87:
(8*7)+(7*8)+(6*4)+(5*2)+(4*1)+(3*0)+(2*8)+(1*7)=173
173 % 10 = 3
So 784210-87-3 is a valid CAS Registry Number.

784210-87-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[3-[4-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]phenyl]-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-ylurea,dihydrochloride

1.2 Other means of identification

Product number -
Other names Urea,N-(1,4-dihydro-3-(4-((4-(2-methoxyethyl)-1-piperazinyl)methyl)phenyl)-4-oxoindeno(1,2-c)pyrazol-5-yl)-N'-4-morpholinyl-,dihydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:784210-87-3 SDS

784210-87-3Upstream product

784210-87-3Downstream Products

784210-87-3Relevant articles and documents

USES OF KINASE INHIBITORS AND COMPOSITIONS THEREOF

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Page/Page column 93; 99, (2008/06/13)

The invention pertains to inhibitors of various kinases (e.g. S/T kinases, Tyr kinases, etc.), which inhibitors are previously known as cyclin dependent kinase inhibitors (CDKs). As described herein, the inhibitors of this invention are capable of inhibit

Inhibitors of cyclin-dependent kinases, compositions and uses related thereto

-

, (2008/06/13)

The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.

INHIBITORS OF CYCLIN-DEPENDENT KINASES, COMPOSITIONS AND USES RELATED THERETO

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Page 85-86, (2008/06/13)

The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machiner

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