Construction of a quaternary carbon at the carbonyl carbon of the cyclohexane ring
High SN2′ selectivity in the allylic substitution of cyclohexylidene ethyl picolinates with copper reagents prepared from RMgBr and CuBr·Me2S was realized by addition of ZnX2 (X = I, Br, Cl). Furthermore, ZnX2 accelerated the reaction with the bulky iPr reagent. The Royal Society of Chemistry 2010.
Kaneko, Yuki,Kiyotsuka, Yohei,Acharya, Hukum P.,Kobayashi, Yuichi
supporting information; experimental part
p. 5482 - 5484
(2010/10/04)
SYNTHESIS OF TRANS-4-ALKYL-1-PHENYLCYCLOHEXANES AND THEIR DERIVATIVES
The alkylation of benzene by 1-alkanoyl-2-chlorocyclohexanes and 1-alkanoyl-1-cyclohexenes leads to the formation of cis- and trans-4-alkanoyl-1-phenylcyclohexanes, the yields of which increase with increase in the reaction temperature. trans-4-Alkyl-1-phenylcyclohexanes were obtained from 4-alkanoyl-1-phenylcyclohexanes and also from the products from the reaction of 4-alkylcyclohexanones with phenylmagnesium bromide.Some mesomorphous derivatives of these hydrocarbons were synthesized.
Bezborodov, V. S.,Bubel', O. N.,Konovalov, V. A.,Ptashnikov, Yu. L.
p. 1479 - 1483
(2007/10/02)
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