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786685-86-7

4-(4-Fluorophenyl)-2-fluorobenzoic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 786685-86-7 Structure

  • Basic information

    1. Product Name: 4-(4-Fluorophenyl)-2-fluorobenzoic acid
    2. Synonyms: 4-(4-Fluorophenyl)-2-fluorobenzoic acid;2-FLUORO-4-(4-FLUOROPHENYL)BENZOIC ACID
    3. CAS NO:786685-86-7
    4. Molecular Formula: C13H8F2O2
    5. Molecular Weight: 234.1982264
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 786685-86-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(4-Fluorophenyl)-2-fluorobenzoic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(4-Fluorophenyl)-2-fluorobenzoic acid(786685-86-7)
    11. EPA Substance Registry System: 4-(4-Fluorophenyl)-2-fluorobenzoic acid(786685-86-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 786685-86-7(Hazardous Substances Data)

786685-86-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 786685-86-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,8,6,6,8 and 5 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 786685-86:
(8*7)+(7*8)+(6*6)+(5*6)+(4*8)+(3*5)+(2*8)+(1*6)=247
247 % 10 = 7
So 786685-86-7 is a valid CAS Registry Number.

786685-86-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-fluoro-4-(4-fluorophenyl)benzoic acid

1.2 Other means of identification

Product number -
Other names 3,4'-difluoro-biphenyl-4-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:786685-86-7 SDS

786685-86-7Downstream Products

786685-86-7Relevant articles and documents

Design, synthesis, and structure-activity relationship studies of L-amino alcohol derivatives as broad-spectrum antifungal agents

Zhao, Liyu,Tian, Linfeng,Sun, Nannan,Sun, Yin,Chen, Yixuan,Wang, Xinran,Zhao, Shizhen,Su, Xin,Zhao, Dongmei,Cheng, Maosheng

, p. 374 - 385 (2019/06/05)

To discover broad spectrum antifungal agents, two strategies were applied, and a novel class of L-amino alcohol derivatives were designed and synthesized. 3-F substituted compounds 14i, 14n, 14s and 14v exhibited excellent antifungal activities with broad antifungal spectra against C. albicans and C. tropicalis, with MIC values in the range of 0.03–0.06 μg/mL, and against A. fumigatus and C. neoformans, with MIC values in the range of 1–2 μg/mL. Notably, Compounds 14i, 14n, 14s and 14v also displayed moderate activities against fluconazole-resistance strains 17# and CaR that were isolated from AIDS patients. Moreover, only compounds in the S-configuration showed antifungal activity. Preliminary mechanistic studies showed that the potent antifungal activity of compound 14v stemmed from inhibition of C. albicans CYP51. Compounds 14n and 14v were almost nontoxic to mammalian A549 cells, and their stability in human plasma was excellent.

Rational development of 4-aminopyridyl-based inhibitors targeting trypanosoma cruzi CYP51 as anti-chagas agents

Choi, Jun Yong,Calvet, Claudia M.,Gunatilleke, Shamila S.,Ruiz, Claudia,Cameron, Michael D.,McKerrow, James H.,Podust, Larissa M.,Roush, William R.

, p. 7651 - 7668 (2013/11/06)

A new series of 4-aminopyridyl-based lead inhibitors targeting Trypanosoma cruzi CYP51 (TcCYP51) has been developed using structure-based drug design as well as structure-property relationship (SPR) analyses. The screening hit starting point, LP10 (KD ≤ 42 nM; EC50 = 0.65 μM), has been optimized to give the potential leads 14t, 27i, 27q, 27r, and 27t, which have low-nanomolar binding affinity to TcCYP51 and significant activity against T. cruzi amastigotes cultured in human myoblasts (EC50 = 14-18 nM for 27i and 27r). Many of the optimized compounds have improved microsome stability, and most are selective against human CYPs 1A2, 2D6, and 3A4 (50% inhibition at 1 μM). A rationale for the improvement in microsome stability and selectivity of inhibitors against human metabolic CYP enzymes is presented. In addition, the binding mode of 14t with the Trypanosoma brucei CYP51 (TbCYP51) orthologue has been characterized by X-ray structure analysis.

INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS

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Page 13, (2010/02/10)

The present invention relates to compounds of Formula I: I which are agonists of the M-1 muscarinic receptor.

MUSCARINIC AGONISTS

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Page 14, (2010/02/09)

The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.

MUSCARINIC AGONISTS

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Page 14, (2010/02/09)

The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.

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