Palladium-Catalyzed Carbothiolation via Trapping of the σ-Alkyl Palladium Intermediate with RSTIPS
A palladium-catalyzed carbothiolation via the reaction of a σ-alkyl palladium intermediate with a TIPS thioether is described. It was found that the use of Cs2CO3, (IPr)Pd(allyl)Cl, and a TIPS thioether was key to obtaining alkyl aryl and dialkyl sulfides in high yield through the reaction of a σ-alkyl palladium intermediate. The developed reaction is applicable to a wide range of substrates and thiols.
Formation of Dihydrobenzofurans by Radical Cyclization
A survey of methods for the generation of aryl radicals from o-alkenyloxyarene diazonium salts demonstrates that dihydrobenzofuran derivatives can be efficiently formed by treatment of (1) or (2) with Bun3SnH-Et2O or with NaI-Me2CO; methods utilising the iodo-compound (3; X = I) are less effective.
Beckwith, Athelstan L. J.,Meijs, Gordon F.
p. 136 - 137
(2007/10/02)
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