787586-82-7

Basic information

• Product Name: 5-(4-FLUORO-PHENYL)-1-METHYL-1H-IMIDAZOL-2-YLAMINE
• Synonyms: 5-(4-FLUORO-PHENYL)-1-METHYL-1H-IMIDAZOL-2-YLAMINE;5-(4-fluorophenyl)-1-methylimidazol-2-amine
• CAS NO: 787586-82-7
• Molecular Formula: C₁₀H₁₀FN₃
• Molecular Weight: 191.2
• Mol File: 787586-82-7.mol

Chemical Properties

• Melting Point: 215-217 °C
• Boiling Point: 387.7±34.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• PKA: 7.92±0.43(Predicted)
• CAS DataBase Reference: 5-(4-FLUORO-PHENYL)-1-METHYL-1H-IMIDAZOL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-FLUORO-PHENYL)-1-METHYL-1H-IMIDAZOL-2-YLAMINE(787586-82-7)
• EPA Substance Registry System: 5-(4-FLUORO-PHENYL)-1-METHYL-1H-IMIDAZOL-2-YLAMINE(787586-82-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 787586-82-7(Hazardous Substances Data)

Upstream product

• 1042275-80-8 5-(4-fluorophenyl)-1-methyl-N-[(1E,2E)-3-piperidin-1-ylprop-2-enylidene]-1H-imidazol-2-ylamine 
• 787586-61-2 2-(4-fluorophenyl)-1-methylimidazo[1,2-a]pyrimidin-1-ium perchlorate 

Relevant articles and documents

A divergent synthesis of substituted 2-aminoimidazoles from 2-aminopyrimidines

(Chemical Equation Presented) A new divergent and efficient synthesis of substituted 2-aminoimidazoles 5 and 6 has been developed starting from the readily available 2-aminopyrimidines 1 and α-bromocarbonyl compounds 2, using conventional heating or microwave irradiation. Thus, the cleavage of 1,2,3-substituted imidazo[1,2-a]pyrimidin-1-ium salts 4 with hydrazine or secondary amines led to 1,4,5-trisubstituted 2-aminoimidazoles 5, when the hydrazinolysis of 2-hydroxy-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium salts 3, followed by a novel Dimroth-type rearrangement, resulted in formation of 2-amino-1H-imidazoles 6. The relevant pathway of transformations was identified by characterization of the intermediates.