Design and synthesis of novel potent antinociceptive agents: Methyl-imidazolyl N-acylhydrazone derivatives
This paper describes recent results of design, synthesis and pharmacological evaluation of new N-heterocyclic functionalized N-acylhydrazone compounds, belonging to the 2-methyl-imidazolyl-3-acylhydrazone class (4a-e). These compounds were planned by applying the molecular simplification strategy to propose the structural modifications on the previously described functionalized imidazo[1,2-a]pyridine 3-acylhydrazone series (2), which presented an important analgesic profile. This new series (4) was synthesized in order to investigate the possible pharmacophoric contribution of the N-heteroaromatic ring and N-acylhydrazone moieties to the analgesic activity. Compounds 4a-b are the most potent antinociceptive agents from this series. Copyright (C) 2000 Elsevier Science Ltd.
Figueiredo, Juliana M.,Camara, Celso De A.,Amarante, Emanuel G.,Miranda, Ana Luisa P.,Santos, Fulvia M.,Rodrigues, Carlos R.,Fraga, Carlos Alberto M.,Barreiro, Eliezer J.
p. 2243 - 2248
(2007/10/03)
Process for preparing 5-methyl-4-imidazolecarboxylic acid esters
A process for the preparation of 5-methyl-4-imidazolecarboxylic acid esters from acetoacetic acid esters. The products of this process are useful as intermediates for preparing cimetidine.
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(2008/06/13)
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