Synthesis and Pharmacological Evaluation of Novel Pyrazolyl Piperidine Derivatives as Effective Antiplatelet Agents
The synthesis and antiplatelet activity of substituted pyrazolyl piperidine derivatives (3a–n) are described. These compounds were synthesized by an improved ring opening reaction of 2-arylidene quinuclidinone using hydrazine hydrate under mild conditions
Soni, Jigar Y.,Tamboli, Riyaj S.,Giridhar, Rajani,Yadav, Mange Ram,Thakore, Sonal
p. 1279 - 1286
(2017/03/27)
Search for NO donors. Part I. 3-quinuclidone oximes
SYNTHESIS AND THREE-DIMENSIONAL STRUCTURE OF 2-ARYLIDENE-3-OXOQUINUCLIDINE OXIMES
2-Arylidene-3-oxoquinuclidine oximes were obtained from the products of condensation of 3-oxoquinuclidine with aromatic aldehydes.It is shown that three of the four theoretically possible isomers (isomerism involving the C=C and C=N bonds) are formed; their stability was studied.The structures of the isomeric oximes was established on the basis of data from the 1H and 13C NMR spectra and were confirmed by data from chromatographic mass spectrometry and the UV and IR spectra.
Filipenko, T. Ya.,Gorbyleva, O. I.,Turchin, K. F.,Anisimova, O. S.,Peresleni, E. M.,et al.
p. 490 - 497
(2007/10/02)
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