- Preparation methods of 2-[(2-benzothiazolylmethyl)thio]-6-ethoxybenzothiazole and intermediates thereof
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The invention provides a preparation method of 2-[(2-benzothiazolylmethyl)thio]-6-ethoxybenzothiazole. The method includes reacting a compound (II) and a compound (III) in a solvent under an alkalinecondition with or without a catalyst to obtain a compound (I) that is the 2-[(2-benzothiazolylmethyl)thio]-6-ethoxybenzothiazole. The invention further provides a preparation method of the compound (II), including reacting a compound (IV) with a nitrosation agent and a copper agent in order in a solvent. The invention further provides a preparation method of the compound (III), including reactinga compound (V) with a sulfurizing agent in a solvent to obtain the compound (III). According to the methods, raw materials are cheap and easily available or easy to prepare, reaction conditions are mild, and selectivity and yields are high. The intermediates and a product are purified through crystallization instead of column chromatography and the methods are suitable for industrialization.
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Page/Page column 7-11
(2018/12/02)
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- Synthesis, antioxidant properties and radioprotective effects of new benzothiazoles and thiadiazoles
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In this work, we report the synthesis and characterization of new compounds derived from benzothiazoles and thiadiazoles. We observed that structural modifications on these skeletons affected the antioxidant activity. Thiol and aminothiol compounds derived from thiadiazoles and benzothiazoles showed an interesting antioxidant property. The radioprotective activity has also been evaluated in mice. Some of these compounds could be good radioprotectors.
- Cressier, Damien,Prouillac, Caroline,Hernandez, Pierre,Amourette, Christine,Diserbo, Michel,Lion, Claude,Rima, Ghassoub
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experimental part
p. 5275 - 5284
(2009/12/04)
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- Preparation and use of aryl alkyl acid derivatives for the treatment of obesity
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This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
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- Benzothiazoles and benzoxazoles, drugs containing them, their use and methods of preparing them
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The invention relates to benzothiazoles and benzoxazoles of general formula STR1 wherein R1 to R3, X, Z and n are defined as in claim 1, the enantiomers, diastereomers and salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable properties, particularly an inhibitory effect on cholesterol biosynthesis, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them.
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