Chemoenzymatic synthesis and high-throughput screening of an aminoglycoside-polyamine library: Identification of high-affinity displacers and DNA-binding ligands
Chemoenzymatic parallel synthesis and high-throughput screening were employed to develop a multivalent aminoglycoside-polyamine library for use as high-affinity cation-exchange displacers and DNA-binding ligands. Regioselective lipase-catalyzed acylation,
Rege, Kaushal,Hu, Shanghui,Moore, James A.,Dordick, Jonathan S.,Cramer, Steven M.
p. 12306 - 12315
(2007/10/03)
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