STEREOSPECIFIC SYNTHESIS OF 2-AMINO-3-FLUORONITRILES. PREPARATION OF β-FLUORO-α-AMINO ACID AND ESTERS
The synthesis of some 2-amino-3-fluoro-nitriles and 2-amino-3-fluoro-acids and their esters have been achieved by means of a Strecker-type reaction.The method involved the action of amines with 3-fluoro-2-hydroxy-nitriles followed by acid solvolysis.The f
Ayi, A. I.,Guedj, R.
p. 137 - 152
(2007/10/02)
NOUVELLE VOIE DE SYNTHESE D'ACIDES AMINES MONOFLUORES
Ring opening of the glycidonitriles (IIa-e) by HF/pyridine leads to the fluorocyanohydrins (IIIa-e).Treatment of the nitriles (IIIa-e) with ammonia in methanol gives the α-amino-β-fluoro nitriles (IVa-e) which upon acidic hydrolysis afford the β-fluoro-α-
Ayi, A. I.,Remli, M.,Guedj, R.
p. 1505 - 1508
(2007/10/02)
NEW SYNTHETIC ROUTES TO β-FLUORO-α-AMINOACIDS B - FROM GLYCIDONITRILES
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Ayi, A. I.,Remli, M.,Guedj, R.
p. 540 - 541
(2007/10/02)
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