- Novel Tetracyclic Spiropiperidines. II. Synthesis of 2-Aryl-2,3-dihydrospiro
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A series of 2-aryl-2,3-dihydrospiro has been synthesized as potential psychotropic agents via an efficient intramolecular fluorine displacement reaction.Treatment of a key intermediate, 4-cyano-4-(2-fluorophenyl)-1-methylpiperidine (2), with a large excess of phenylmagnesium bromide in refluxing tetrahydrofuran led to some 2-arylspiro derivatives, 10 and 11, whose structures are elucidated on the basis of chemical and spectral evidence.
- Ong, Helen H.,Agnew, Marc N.
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p. 815 - 820
(2007/10/02)
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