Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)- N′-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): A radiolabelled glycogen synthase kinase-3β specific inhibitor for PET studies
N-(4-Methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea (AR-A014418), a highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β), was radiolabelled with carbon-11 (half-life = 20.4 min) for cerebral positron emission tomography (PET) studies. Reac
Vasdev, Neil,Garcia, Armando,Stableford, Winston T.,Young, Alex B.,Meyer, Jeffrey H.,Houle, Sylvain,Wilson, Alan A.