Reductive amination of 3-Ketoanguidin and Antitumor Activity of the Products
Amine-containing trichothecanes were prepared by reductive aminations of 3-ketoanguidin.In in vivo tests against P388 leukemia, most of them showed an improved activity compared to anguidin though their potency was decreased. 3-Ketoanguidin also produced some unexpected structures: oxazoline 5, dioxaline 7, and α-amino nitrile 13.
Kaneko, T.,Wong, H.,Howell, H. G.,Rose, W. C.,Bradner, W. T.,Doyle, T. W.
p. 958 - 960
(2007/10/02)
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