79352-80-0 Usage
Uses
Used in Pharmaceutical Industry:
INTERMEDIATE is used as a starting material for the synthesis of various pharmaceutical chemicals. It plays a crucial role in the development of new drugs and medicines, as it undergoes further chemical reactions to produce the desired active ingredients.
Used in Dye Industry:
INTERMEDIATE is used as a precursor in the production of dyes. It undergoes a series of chemical reactions to form the final dye product, which is then used in various applications such as textiles, plastics, and printing inks.
Used in Chemical Industry:
INTERMEDIATE is used as a building block in the synthesis of various chemicals and materials. It serves as a key component in the production of polymers, resins, and other specialty chemicals, contributing to the development of new and innovative products in the chemical industry.
Used in Cosmetic Industry:
INTERMEDIATE is used as a raw material in the formulation of cosmetics and personal care products. It undergoes further processing to create active ingredients and additives that enhance the performance and efficacy of these products.
Used in Agrochemical Industry:
INTERMEDIATE is used as a starting point for the synthesis of agrochemicals, such as pesticides and fertilizers. It plays a vital role in the development of products that help improve crop yield and protect plants from pests and diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 79352-80-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,3,5 and 2 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 79352-80:
(7*7)+(6*9)+(5*3)+(4*5)+(3*2)+(2*8)+(1*0)=160
160 % 10 = 0
So 79352-80-0 is a valid CAS Registry Number.
79352-80-0Relevant articles and documents
Antimalarial Pyrido[1,2- a]benzimidazole Derivatives with Mannich Base Side Chains: Synthesis, Pharmacological Evaluation, and Reactive Metabolite Trapping Studies
Okombo, John,Brunschwig, Christel,Singh, Kawaljit,Dziwornu, Godwin Akpeko,Barnard, Linley,Njoroge, Mathew,Wittlin, Sergio,Chibale, Kelly
, p. 372 - 384 (2019/01/26)
A novel series of pyrido[1,2-a]benzimidazoles bearing Mannich base side chains and their metabolites were synthesized and evaluated for in vitro antiplasmodium activity, microsomal metabolic stability, reactive metabolite (RM) formation, and in vivo antimalarial efficacy in a mouse model. Oral administration of one of the derivatives at 4 × 50 mg/kg reduced parasitemia by 95% in Plasmodium berghei-infected mice, with a mean survival period of 16 days post-treatment. The in vivo efficacy of these derivatives is likely a consequence of their active metabolites, two of which showed potent in vitro antiplasmodium activity against chloroquine-sensitive and multidrug-resistant Plasmodium falciparum (P. falciparum) strains. Rapid metabolism was observed for all the analogues with 40% of parent compound remaining after 30 min of incubation in liver microsomes. RM trapping studies detected glutathione adducts only in derivatives bearing 4-aminophenol moiety, with fragmentation signatures showing that this conjugation occurred on the phenyl ring of the Mannich base side chain. As with amodiaquine (AQ), interchanging the positions of the 4-hydroxyl and Mannich base side group or substituting the 4-hydroxyl with fluorine appeared to block bioactivation of the AQ-like derivatives though at the expense of antiplasmodium activity, which was significantly lowered.
