- Visible-light mediated carbamoyl radical addition to heteroarenes
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The generation of carbamoyl radicals, followed by their addition to heteroarenes, was performed under mild conditions through a metal-free photocatalyzed decarboxylation of oxamic acids. The process has been applied to the carbamoylation of heteroaromatic bases using α-aminoacid-derived oxamic acids, leading to the corresponding amides without racemization.
- Jatoi, Ashique Hussain,Pawar, Govind Goroba,Robert, Frédéric,Landais, Yannick
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p. 466 - 469
(2019/01/10)
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- Improved microwave synthesis of unsymmetrical N,N'-diaryl-1,2-aminoethane and imidazolidinium salts as precursors of N-heterocyclic carbenes
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Lithium aluminium hydride reduction of bis-unsymmetric-diaryloxamides 3 is difficult to accomplish especially for the sterically hindered mesityl derivative. Using microwaves LAH reduction of 3a,d was successful in a short time, however, with cleavage of the ether linkage to give compounds 11a,d. Extension of this method enabled the reduction of bis-oxamide derivatives 13 to the corresponding tetraamine derivative 14 which was then converted to the bis-imidazolidinium salt 15. Application of this method led to rapid reduction of unsymmetric N,N'-diaryloxamides 16 to the corresponding N,N'- diarylethylenediamines 17 which were converted to their corresponding imidazolidinium salts 18. the Partner Organisations 2014.
- Ibrahim, Yehia A.,Al-Awadi, Nouria A.,Al-Azemi, Talal F.,John, Elizabeth
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p. 38869 - 38876
(2014/11/08)
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- Synthesis of amino acid derived imidazolidinium salts as new NHC precatalysts
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The preparation of new chiral symmetrically and unsymmetrically N,N′-disubstituted imidazolium based NHC salts Ib, IIb, IIIa-c and IVc-h from the amino acids l-proline and l-phenylalanine, is reported. Some preliminary tests have been carried out, demonstrating that the chiral NHCs give chiral induction in organometallic catalysis and can be used as organocatalysts.
- Strand, Ragnhild B.,Helgerud, Trygve,Solvang, Tina,Sperger, Christian A.,Fiksdahl, Anne
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p. 1994 - 2006
(2012/03/22)
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