79360-43-3

Basic information

• Product Name: Nocloprost
• Synonyms: (5Z,13E,15R)-9β-Chloro-11α,15-dihydroxy-16,16-dimethylprosta-5,13-dien-1-oic acid;SH-475;Nocloprost
• CAS NO: 79360-43-3
• Molecular Formula: C₂₂H₃₇ClO₄
• Molecular Weight: 400.983
• Mol File: 79360-43-3.mol

Chemical Properties

• Boiling Point: 539.8°C at 760 mmHg
• Flash Point: 280.3°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 6.61E-14mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: Nocloprost(CAS DataBase Reference)
• NIST Chemistry Reference: Nocloprost(79360-43-3)
• EPA Substance Registry System: Nocloprost(79360-43-3)

Safety Data

• Hazardous Substances Data: 79360-43-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Nocloprost is used as a pharmaceutical agent for its ability to stimulate the adenylate cyclase enzyme. This stimulation can lead to various therapeutic effects, making it a valuable compound in the development of new medications.
Used in Mucosal Protection:
Nocloprost is used as a mucosal protective drug due to its potential to protect and repair the mucosal lining in the body. This application can be particularly beneficial in treating conditions that affect the mucosal lining, such as inflammatory bowel diseases or other gastrointestinal disorders.

InChI:InChI=1/C22H37ClO4/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6-,13-12+/t16-,17-,18-,19-,20-/m1/s1

Upstream product

• 79360-44-4 (+/-)-(Z)-7-{(1R,2R,3R,5R)-5-chloro-3-hydroxy-2-[(E)-(3R)-3-hydroxy-4,4-dimethyl-1-octenyl]-cyclopentyl}-5-heptenic acid methyl ester 

Relevant articles and documents

Process for the production of 9beta-chloroprostaglandins

The invention relates to a process for the production of (5-chloro-3-hydroxycyclopentyl) acetaldehydes of formula II STR1 in which R signifies a benzyl radical, a tert-butyldimethylsilyl radical or a tert-butyldiphenylsilyl radical, characterized in that

Pharmaceutically active 9-chloroprostaglandins

Compounds of the formula STR1 wherein the 9-chlorine atom can be in the α- or β-position, R1 is OR2, or NHR3 wherein R3 is H or the acyl group of a C1-15 hydrocarbon carboxylic or sulfonic acid; A is --CH2 --CH2 -- or cis--CH=CH--, B is --CH2 --CH2 --,trans--CH=CH--, or --C C--, STR2 wherein the OH-group in each case can be in the α- or β-position, and can be etherified or esterified by tetrahydropyranyl, tetrahydrofuranyl, α-ethoxyethyl, trimethylsilyl dimethyl, tert-butylsilyl, tribenzylsilyl, acetyl, propionyl, butyryl or benzoyl; D and E together represent a direct bond or D is a straight-chain or branched alkylene group of 1-10 carbon atoms, optionally substituted by fluorine, and E is oxygen or sulfur or a direct bond, and R4 is hydroxy or hydroxy etherified or esterified as defined for W above; R5 is a C1-10 hydrocarbon aliphatic group; a C1-10 hydrocarbon, aliphatic group substituted by aryl, a substituted aryl as defined for R2 above, or halogen; or cycloalkyl, substituted cycloalkyl, aryl, substituted aryl or aromatic heterocyclic, all as defined for R2 above; or a physiologically acceptable salt thereof with a base when R1 is OH, have valuable pharmacological properties.