- Containing-containing layer C(sp2 Process)-N for the preparation of a bond-containing compound
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The invention discloses a preparation method of a compound containing C (sp2)-N bonds as shown in a formula I. The preparation method includes the step: performing constant-current electrolysis reaction on a compound as shown in a formula II and a compoun
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Paragraph 0098-0101; 0105-0107
(2020/01/12)
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- Copper-Catalyzed Electrochemical C-H Amination of Arenes with Secondary Amines
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Electrochemical oxidation represents an environmentally friendly solution to conventional methods that require caustic stoichiometric chemical oxidants. However, C-H functionalizations merging transition-metal catalysis and electrochemical techniques are, to date, largely confined to the use of precious metals and divided cells. Herein, we report the first examples of copper-catalyzed electrochemical C-H aminations of arenes at room temperature using undivided electrochemical cells, thereby providing a practical solution for the construction of arylamines. The use of n-Bu4NI as a redox mediator is crucial for this transformation. On the basis of mechanistic studies including kinetic profiles, isotope effects, cyclic voltammetric analyses, and radical inhibition experiments, the reaction appears to proceed via a single-electron-transfer (SET) process, and a high valent Cu(III) species is likely involved. These findings provide a new avenue for transition-metal-catalyzed electrochemical C-H functionalization reactions using redox mediators.
- Yang, Qi-Liang,Wang, Xiang-Yang,Lu, Jia-Yan,Zhang, Li-Pu,Fang, Ping,Mei, Tian-Sheng
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supporting information
p. 11487 - 11494
(2018/09/13)
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- Copper-catalyzed carboxamide-directed ortho amination of anilines with alkylamines at room temperature
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In this report, a highly efficient method for the room temperature installation of alkyl amino motifs onto the ortho position of anilines via Cu-catalyzed carboxamide-directed amination with alkylamines is described. This method offers a practical solution for the rapid synthesis of complex arylamines from simple starting materials and enables new planning strategies for the construction of arylamine-containing pharmacophores. A single electron transfer (SET)-mediated mechanism is proposed.
- Li, Qiong,Zhang, Shu-Yu,He, Gang,Ai, Zhaoyan,Nack, William A.,Chen, Gong
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supporting information
p. 1764 - 1767
(2014/04/17)
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