794450-92-3Relevant articles and documents
Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4
Kaku, Teppei,Ogura, Kenichiro,Nishiyama, Takahito,Ohnuma, Tomokazu,Muro, Kei,Hiratsuka, Akira
, p. 2093 - 2102 (2004)
Tamoxifen (TAM), a nonsteroidal antiestrogen, is the most widely used drug for chemotherapy of hormone-dependent breast cancer in women. In the present study, we found a new potential metabolic pathway of TAM via N-linked glucuronic acid conjugation for e
Glucuronidation of dihydrotestosterone and trans-androsterone by recombinant UDP-glucuronosyltransferase (UGT) 1A4: Evidence for multiple UGT1A4 aglycone binding sites
Zhou, Jin,Tracy, Timothy S.,Remmel, Rory P.
experimental part, p. 431 - 440 (2011/02/27)
UDP-glucuronosyltransferase (UGT) 1A4-catalyzed glucuronidation is an important drug elimination pathway. Although atypical kinetic profiles (nonhyperbolic, non-Michaelis-Menten) of UGT1A4-catalyzed glucuronidation have been reported occasionally, systema