Copper(I)-catalyzed cascade synthesis of 2-substituted 1,3-benzothiazoles: Direct access to benzothiazolones
An efficient cascade process for the preparation of 2-substituted 1,3-benzothiazoles directly from 2-haloaryl isothiocyanates and O or S nucleophiles by a Cu-catalyzed, intramolecular, C-S bond formation has been developed. This cascade method is viable f
Murru, Siva,Mondal, Pravat,Yella, Ramesh,Patel, Bhisma K.
experimental part
p. 5406 - 5413
(2010/02/28)
Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors
The synthesis and biological evaluation of a series of aryl diamines as inhibitors of LTA4-h inhibitors are described. The optimization which led to the identification of the optimal para-substitution on the diphenyl ether moiety and diamine spacer is discussed. The resulting compounds such as 3l have excellent enzyme and cellular potency as well as desirable pharmacokinetic properties.
Khim, Seock-Kyu,Bauman, John,Evans, Jarred,Freeman, Beverly,King, Beverly,Kirkland, Thomas,Kochanny, Monica,Lentz, Dao,Liang, Amy,Mendoza, Lisa,Phillips, Gary,Tseng, Jih-Lie,Wei, Robert G.,Ye, Hong,Yu, Limei,Parkinson, John,Guilford, William J.
scheme or table
p. 3895 - 3898
(2009/04/07)
PHOSPHORYLATION OF HETEROCYCLIC COMPOUNDS. I. TRIPHENYL-2-HETERYLPHOSPHONIUM SALTS
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Zhmurova, I. N.,Kosinskaya, I. M.,Pinchuk, A. M.
p. 1304 - 1307
(2007/10/02)
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