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11-HYDROXY-6,11-DIHYDRO-DIBENZO[B,E]OXEPINE-2-CARBOXYLIC ACID METHYL ESTER, also known as clozapine N-oxide (CCNO), is a chemical compound derived from clozapine, an antipsychotic medication. It has been extensively studied for its potential therapeutic effects on the central nervous system, particularly in the context of schizophrenia and other psychiatric disorders. CCNO interacts with various neurotransmitter systems in the brain, such as dopamine and serotonin receptors, which are implicated in the development of psychiatric conditions. Ongoing research suggests that CCNO may emerge as a promising treatment option for certain psychiatric disorders in the future.

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  • 11-HYDROXY-6,11-DIHYDRO-DIBENZO[B,E]OXEPINE-2-CARBOXYLICACIDMETHYLESTER

    Cas No: 79669-90-2

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  • 79669-90-2 Structure
  • Basic information

    1. Product Name: 11-HYDROXY-6,11-DIHYDRO-DIBENZO[B,E]OXEPINE-2-CARBOXYLIC ACID METHYL ESTER
    2. Synonyms: 11-HYDROXY-6,11-DIHYDRO-DIBENZO[B,E]OXEPINE-2-CARBOXYLIC ACID METHYL ESTER;METHYL 11-HYDROXY-6,11-DIHYDRODIBENZO[B,E]OXEPINE-2-CARBOXYLATE
    3. CAS NO:79669-90-2
    4. Molecular Formula: C16H14O4
    5. Molecular Weight: 270.28
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 79669-90-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 11-HYDROXY-6,11-DIHYDRO-DIBENZO[B,E]OXEPINE-2-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
    10. NIST Chemistry Reference: 11-HYDROXY-6,11-DIHYDRO-DIBENZO[B,E]OXEPINE-2-CARBOXYLIC ACID METHYL ESTER(79669-90-2)
    11. EPA Substance Registry System: 11-HYDROXY-6,11-DIHYDRO-DIBENZO[B,E]OXEPINE-2-CARBOXYLIC ACID METHYL ESTER(79669-90-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 79669-90-2(Hazardous Substances Data)

79669-90-2 Usage

Uses

Used in Pharmaceutical Research:
11-HYDROXY-6,11-DIHYDRO-DIBENZO[B,E]OXEPINE-2-CARBOXYLIC ACID METHYL ESTER is used as a research compound for investigating its potential therapeutic effects on the central nervous system. Its interaction with neurotransmitter systems, such as dopamine and serotonin receptors, makes it a valuable candidate for studying the underlying mechanisms of psychiatric disorders and developing novel treatment strategies.
Used in Schizophrenia Treatment Research:
In the field of schizophrenia research, 11-HYDROXY-6,11-DIHYDRO-DIBENZO[B,E]OXEPINE-2-CARBOXYLIC ACID METHYL ESTER is used as a potential treatment option. Its ability to modulate neurotransmitter systems involved in the disorder's pathophysiology positions it as a promising candidate for further investigation and development as a therapeutic agent.
Used in Other Psychiatric Disorders Research:
Beyond schizophrenia, 11-HYDROXY-6,11-DIHYDRO-DIBENZO[B,E]OXEPINE-2-CARBOXYLIC ACID METHYL ESTER is also used in research aimed at understanding and treating other psychiatric disorders. Its interaction with key neurotransmitter systems suggests that it may have broader applications in the field of psychiatry, warranting further exploration of its potential benefits and mechanisms of action.

Check Digit Verification of cas no

The CAS Registry Mumber 79669-90-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,6,6 and 9 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 79669-90:
(7*7)+(6*9)+(5*6)+(4*6)+(3*9)+(2*9)+(1*0)=202
202 % 10 = 2
So 79669-90-2 is a valid CAS Registry Number.

79669-90-2Downstream Products

79669-90-2Relevant articles and documents

Non-prostanoid thromboxane A2 receptor antagonists with a dibenzoxepin ring system. 1

Ohshima,Takami,Sato,Obase,Miki,Ishii,Karasawa,Kubo

, p. 3394 - 3402 (2007/10/02)

A series of 11-[[2-[(arylsulfonyl)amino]ethyl]thio]-6,11- dihydrodibenz[b,e]oxepin-2-carboxylic acids and related derivatives were synthesized. The compounds were tested for their antagonizing effects on guinea pig platelet TXA2/PGH2 receptors. Structure-activity relationships are discussed. (±)-11-[[2-[(Styrylsulfonyl)amino]ethyl]thio]-6,11- dihydrodibenz[b,e]oxepin-2-carboxylic acid (41) and (±)-11-[[2- [(phenylsulfonyl)amino]ethyl]thio]-6,11-dihydrodibenz[b,e]thiepin-2- carboxylic acid (4af) were the most promising compounds with K(i) values of 6.5 ± 0.29 and 3.7 ± 0.31 nM, respectively, for the TXA2/PGH2 receptor. These compounds also significantly inhibited U-46619-induced guinea pig platelet aggregation ex vivo (10 mg/kg po). Compound 41 was resolved into its optically active form. The (-)-isomer was 60-fold more potent than the (+)- isomer in the TXA2/PGH2 receptor binding assay. Some compounds tested in this study showed both TXA2/PGH2 receptor antagonizing and TXA2 synthase inhibitory effects.

TRICYCLIC COMPOUNDS

-

, (2008/06/13)

Novel tricyclic compound represented by formula STR1 possess a TXA. sub.2 biosynthesis inhibiting activity and/or a TXA 2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.

A new series of antiallergic agents. I. Synthesis and activity of 11-(2-aminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin derivatives

Ohshima,Kumazawa,Takizawa,Harakawa,Sato,Obase,Oiji,Ishii,Ishii,Ohmori

, p. 2724 - 2728 (2007/10/02)

A new series of 11-substituted 6,11-dihydrodibenz[b,e]oxepin derivatives was synthesized and evaluated for antiallergic activity. Convenient methods for the preparation of sulfides from alcohols were developed. Structure-activity relationships are described. Compound 7, 11-[2-(dimethylamino)ethyl]thio-6,11-dihydrodibenz[b,e]oxepin-2-carboxy lic acid hydrochloride, was the most potent in the rat passive cutaneous anaphylaxis test (ED50 = 0.92 mg/kg p.o.). It had a potent inhibitory effect on anaphylactic bronchoconstriction in guinea pigs (ED50 = 0.029 mg/kg p.o.) and H1 receptor antagonistic effect (K(i) = 14 nM) with few central nervous system side effects. Additionally, an antagonistic effect against prostagrandin D2-induced contraction of isolated guinea pig trachea (pA2 = 5.73) was an attractive mechanism of action of the new antiallergic agent. Compound 7 was selected for further evaluation as KW-4994.

Tricyclic compounds

-

, (2008/06/13)

Novel tricyclic compounds having a TXA2 -antagonizing activity represented by formula (I): STR1 which strongly antagonize an action of thromboxane A2 and are expected to have preventive and therapeutic effects on ischemica diseases, cerebro-vascular diseases, etc.

Dibenz[b,e]oxepin compounds

-

, (2008/06/13)

Novel dibenz[b,e]oxepin derivatives are employed in the treatment and control of allergic conditions such as allergic asthma.

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