796738-74-4

Basic information

• Product Name: N-[4-[[4-(Chloromethyl)benzoyl]amino]-2-methylphenyl]-4-(3-pyridyl)-2-pyrimidineamine
• Synonyms: N-[4-[[4-(Chloromethyl)benzoyl]amino]-2-methylphenyl]-4-(3-pyridyl)-2-pyrimidineamine;4-(ChloroMethyl)-N-[3-Methyl-4-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]phenyl]benzaMide
• CAS NO: 796738-74-4
• Molecular Formula: C24H20ClN5O
• Molecular Weight: 429.9015
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 796738-74-4.mol

Chemical Properties

• Appearance: /
• Density: 1.329±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Sparingly), Methanol (Sparingly)
• PKA: 12.88±0.70(Predicted)
• CAS DataBase Reference: N-[4-[[4-(Chloromethyl)benzoyl]amino]-2-methylphenyl]-4-(3-pyridyl)-2-pyrimidineamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-[[4-(Chloromethyl)benzoyl]amino]-2-methylphenyl]-4-(3-pyridyl)-2-pyrimidineamine(796738-74-4)
• EPA Substance Registry System: N-[4-[[4-(Chloromethyl)benzoyl]amino]-2-methylphenyl]-4-(3-pyridyl)-2-pyrimidineamine(796738-74-4)

Safety Data

• Hazardous Substances Data: 796738-74-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-[4-[[4-(Chloromethyl)benzoyl]amino]-2-methylphenyl]-4-(3-pyridyl)-2-pyrimidineamine is used as an intermediate in the preparation of Imatinib impurities, which are essential for the development and quality control of Imatinib, a medication used to treat certain types of cancer.
Used in COVID-19 Research:
As a COVID-19-related research product, N-[4-[[4-(Chloromethyl)benzoyl]amino]-2-methylphenyl]-4-(3-pyridyl)-2-pyrimidineamine is utilized in the exploration of potential treatments or diagnostic tools for the disease. Its specific application in this context may involve targeting the virus's replication mechanisms or enhancing the host's immune response.

Relevant articles and documents

N-PHENYL-2-PYRIMIDINE-AMINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF

The present invention relates to an N-phenyl-2-pyrimidine-amine derivative showing a superior effect on tumor, lung cancer, gastric cancer, etc. of warm-blooded animals and its salt. The present invention also relates to a process for preparing the compound and a pharmaceutical composition for the prevention and treatment of such diseases as tumor, lung cancer, gastric cancer, etc., which comprises the compound as an active ingredient.

N-PHENYL-2-PYRIMIDINE-AMINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF

The present invention relates to an N-Phenyl-2-pyrimidine-aminine derivative showing a superior effect on lung cancer, gastric cancer, colon cancer, pancreatic cancer, hepatoma, prostatic cancer, breast cancer, chronic or accute leukemia, hematologic malignancy, encephalophyma, bladder cancer, rectal cancer or cervical cancer, etc. of warm blooded animals and its salt. The present invention also relates to a process for preparing the compound, and to a pharmaceutical composition for the treatment of the above various disease, which comprises an effective amount of the compound as an active ingredient together with pharmaceutically acceptable inert carriers.