- Acid-catalyzed synthesis of imidazole derivatives via N-phenylbenzimidamides and sulfoxonium ylides cyclization
-
A straightforward method to synthesize imidazole derivatives from amidines and sulfoxonium ylides catalyzed by acids is reported in this study. Specifically, catalyzed by trifluoroacetic acid in DCE solvents can improve synthesis efficiency under metal-fr
- Tian, Yuan,Qin, Mingda,Yang, Xueying,Zhang, Xueguo,Liu, Yafeng,Guo, Xin,Chen, Baohua
-
p. 2817 - 2823
(2019/04/13)
-
- Copper-Catalyzed Simultaneous Activation of C-H and N-H Bonds: Three-Component One-Pot Cascade Synthesis of Multi?-substituted Imidazoles
-
A copper-catalyzed expedient, practical, and straightforward approach for the one-pot three-component modular synthesis of multisubstituted imidazoles has been described by using arylacetic acids, N -arylbenzamidines, and nitroalkanes. The reaction involv
- Pardeshi, Sachin D.,Sathe, Pratima A.,Vadagaonkar, Kamlesh S.,Melone, Lucio,Chaskar, Atul C.
-
p. 361 - 370
(2018/01/12)
-
- One-Pot Protocol for the Synthesis of Imidazoles and Quinoxalines using N-Bromosuccinimide
-
N-bromosuccinimide (NBS)-mediated one-pot, green, efficient and practical synthesis of substituted imidazoles and quinoxalines has been achieved by the reaction of styrenes with N-arylbenzamidines and o-phenylenediamines, respectively, in a water:1,4-dioxane mixture. The reaction involves formation of an α-bromo ketone as an intermediate in the presence of NBS and water, followed by condensation with the N-arylbenzamidine and o-phenylenediamine. Use of an inexpensive NBS as a bromine source as well as an oxidant, water as a solvent and readily available starting materials makes this protocol environmentally benign and economically viable. Substituted imidazoles and quinoxalines were obtained in good to excellent yields with wide functional group compatibility. (Figure presented.).
- Pardeshi, Sachin D.,Sathe, Pratima A.,Vadagaonkar, Kamlesh S.,Chaskar, Atul C.
-
supporting information
p. 4217 - 4226
(2017/12/07)
-
- A Transition-Metal-Free Synthesis of Multisubstituted Imidazoles
-
A novel and simple t-BuOLi/I2-mediated synthesis of 1,2,4-trisubstituted imidazoles was developed without transition-metal added. The transition-metal-free strategy tolerated a range of substrates and provided products in moderate to good yield
- Wu, Ping,Zhang, Lutao,Zhang, Xueguo,Guo, Xin,Chen, Baohua
-
p. 363 - 367
(2016/04/26)
-
- Copper and zinc co-catalyzed synthesis of imidazoles via the activation of sp3 C-H and N-H bonds
-
An efficient and facile approach to synthesize imidazoles from amidines and arylketone via oxidative coupling of sp3 C-H bond and N-H bond is reported. This strategy exhibits high performance in terms of regioselectivity with moderate to high y
- Tang, Dong,Li, Xiao-Long,Guo, Xin,Wu, Ping,Li, Ji-Hui,Wang, Kai,Jing, Huan-Wang,Chen, Bao-Hua
-
p. 4038 - 4042
(2014/06/09)
-
- Facile synthesis of 1,2,4-trisubstituted imidazoles via aerobic copper catalyzed ligand-free [3+2] cycloaddition
-
A simple and facile approach to highly functionalized imidazole derivatives in moderate to good yields has been developed. This method involves copper catalyzed aerobic [3+2] cycloaddition of amidines with nitroolefins in absence of ligand. Based on observation of the intermediates, possible reaction mechanism different from the same reported approach was proposed.
- Li, Wei,Tian, Weixiang Jiao Wan,Lei, Ming
-
p. 386 - 392
(2014/05/20)
-
- Iron (III)-catalyzed synthesis of 1,2,4-trisubstituted imidazoles through the reactions of amidines and aldehydes in air
-
A novel and efficient iron (III)-catalyzed synthesis of 1,2,4-trisubstituted imidazoles through the reactions of amidines and aldehydes in air has been developed. Five hydrogen dissociations involving C-H and N-H bond activation are realized under mild conditions in this approach. The procedure is sustainable, simple and environmentally friendly.
- Liu, Xiang,Wang, Dong,Chen, Yongxin,Tang, Dong,Chen, Baohua
-
supporting information
p. 2798 - 2802
(2014/03/21)
-
- Copper-catalyzed oxidative diamination of terminal alkynes by amidines: Synthesis of 1,2,4-trisubstituted imidazoles
-
An efficient copper-catalyzed synthesis of 1,2,4-trisubstituted imidazoles using amidines and terminal alkynes has been developed. Overall, the oxidative process, which involves Na2CO3, pyridine, a catalytic amount of CuCl2/sub
- Li, Jihui,Neuville, Luc
-
p. 1752 - 1755
(2013/06/26)
-
- Iron(III)-catalyzed synthesis of multi-substituted imidazoles via [3+2] cycloaddition reaction of nitroolefins and N-aryl benzamidines
-
A novel and efficient iron(III)-catalyzed synthesis of multi-substituted imidazoles via [3+2] cycloaddition of nitroolefins and N-aryl benzamidines under the air atmosphere had been developed. This methodology is convenient, atom-economical, general, and eco-friendly in good yields and prefect regioselectivities.
- Liu, Xiang,Wang, Dong,Chen, Baohua
-
supporting information
p. 9417 - 9421
(2013/10/08)
-
- Synthesis of multisubstituted imidazoles via copper-catalyzed [3 + 2] cycloadditions
-
A simple route for the synthesis of imidazole derivatives via copper-catalyzed [3 + 2] cycloaddition reaction is described. This strategy has achieved high regioselectivity and used oxygen as an oxidant without the addition of expensive catalysts to provide moderate to good yields.
- Tang, Dong,Wu, Ping,Liu, Xiang,Chen, Yong-Xin,Guo, Shuai-Bo,Chen, Wen-Lin,Li, Jia-Gen,Chen, Bao-Hua
-
p. 2746 - 2750
(2013/05/09)
-
- Thermal rearrangements of tetrahydroimidazo[1,5-b]isoxazole-2,3-dicarboxylates. Synthesis of 3H-imidazol-1-ium ylides and their silver derivatives
-
Isoxazolines 2 from the cycloaddition of imidazoline 3-oxides 1 with DMAD undergo rearrangement to 3,4-dihydro-2H-imidazol-1-ium-1-(1,2-bis-methoxycarbonyl-2-oxo-ethanides) 3, which spontaneously undergo elimination to give 3H-imidazol-1-ium-1-(1,2-bis-me
- Co?kun, Necdet,?etin, Meliha
-
experimental part
p. 2053 - 2060
(2010/04/26)
-
- The first regio- and diastereoselective synthesis of homochiral perhydroimidazoisoxazoles via the 1,3-dipolar cycloaddition of imidazoline 3-oxides with (1S)-(-)-β-pinene
-
The 1,3-dipolar cycloaddition of imidazoline 3-oxides 1 with (1S)-(-)-β-pinene proceeds regio- and diastereoselectively to give homochiral perhydroimidazoisoxazole derivatives 3 in high yields in the cases of imidazoline 3-oxides 1a-e but in low yields in
- Coskun, Necdet,Tat, Fatma Tirli,Gueven, Oezden Oezel
-
p. 1463 - 1467
(2007/10/03)
-
- Synthesis of di- and cis-triaryl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazoles and their ring-opening reactions
-
The Δ3-imidazoline 3-oxides 1 undergo diastereoselective cycloaddition with dimethyl acetylenedicarboxylate 2 to give 3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazoles 3. Thermally and base induced ring-opening reactions of compounds 3 were demonstra
- Co?kun, Necdet,Tirli Tat, Fatma,?zel Güven, ?zden
-
p. 3413 - 3417
(2007/10/03)
-
- The first examples of di- and cis triaryl-3a,4,5,6- tetrahydroimidazo[1,5-b]isoxazoles and their ring-opening reactions
-
The Δ3-imidazoline 3-oxides 1 undergo diastereoselective cycloaddition with dimethyl acetylenedicarboxylate 2 to give 3a,4,5,6- tetrahydroimidazo[1,5-b]isoxazoles 3. Thermal and base induced ring-opening reactions of compounds 3 were demonstrat
- Co?kun, Necdet,Tirli Tat, Fatma,Güven, ?zden ?zel,ülkü, Din?er,Arici, Cengiz
-
p. 5407 - 5409
(2007/10/03)
-
- Synthesis of functionalised cyclic nitrones via regioselective and unusual [3 + 2] cycloadditions of α-nitrosostyrenes with 1,3-diazabuta-1,3-dienes and imines
-
The α-nitrosostyrenes 2, generated in situ from α-halogeno oximes, undergo regioselective [3 + 2] cycloaddition with 1,3-diazabuta-1,3-dienes 1 and 5 leading to the cyclic nitrones 3 and 6, respectively. Similarly, the cyclic nitrones 12 are also formed i
- Sharma, Arun K.,Mazumdar, Sujit N.,Mahajan, Mohinder P.
-
p. 3065 - 3070
(2007/10/03)
-
- The Chemistry of Amino Oximes, XIV. Synthesis and Reaction of 2--3-imidazoline 3-Oxides
-
2-Benzoyl-4-phenyl-1-(p-tolyl)-3-imidazoline 3-oxide (3b) has been prepared by cyclocondensation of α-(p-toluidino)acetophenone oxime (1a) with phenylglyoxal and transferred into 2--4-phenyl-1-(p-tolyl)-3-imidazoline 3-oxide (5
- Gnichtel, Horst,Moeller, Bernd
-
p. 3170 - 3175
(2007/10/02)
-