79944-37-9

Basic information

• Product Name: trans-5-Amino-6-hydroxy-2,2-dimethyl-1,3-dioxacyloheptane
• Synonyms: trans-5-Amino-6-hydroxy-2,2-dimethyl-1,3-dioxacyloheptane;L(+)-AMINODIOXEPANE ACETATE;TRANS-5-AMINO-6-HYDROXY-2,2-DIMETHYL-1,3-DIOXACYCLOHEPTANE;TRANS-6-AMINO-5-HYDROXY-2,2-DIMETHYL-1,3-DIOXEPANE ACETATE;(5R,6S)-6-AMINO-2,2-DIMETHYL-1,3-DIOXEPAN-5-OL HYDROCHLORIDE;trans-6-Amino-5-hydroxy-2,2-dimethyl-1,3-dioxepane;(5R, 6S)-6-Amino-2,2-dimethyl-1,3-dioxepan-5-ol;trans-(5RS,6SR)-6-amino-2,2-dimethyl-1,3-dioxepan-5-ol
• CAS NO: 79944-37-9
• Molecular Formula: C7H15NO3
• Molecular Weight: 161.2
• EINECS: 419-050-3
• Mol File: 79944-37-9.mol

Chemical Properties

• Boiling Point: 266.345 °C at 760 mmHg
• Flash Point: 114.881 °C
• Appearance: /
• Density: 1.08 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.458
• CAS DataBase Reference: trans-5-Amino-6-hydroxy-2,2-dimethyl-1,3-dioxacyloheptane(CAS DataBase Reference)
• NIST Chemistry Reference: trans-5-Amino-6-hydroxy-2,2-dimethyl-1,3-dioxacyloheptane(79944-37-9)
• EPA Substance Registry System: trans-5-Amino-6-hydroxy-2,2-dimethyl-1,3-dioxacyloheptane(79944-37-9)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 22-24/25-26-37
• Hazardous Substances Data: 79944-37-9(Hazardous Substances Data)

Usage

Uses

Used in Scientific Research:
Trans-5-Amino-6-hydroxy-2,2-dimethyl-1,3-dioxacycloheptane is used as a research compound for exploring its chemical properties and potential applications in various fields.
Used in Pharmaceutical Development:
trans-5-Amino-6-hydroxy-2,2-dimethyl-1,3-dioxacyloheptane is used as a building block or intermediate in the synthesis of specific pharmaceuticals, given its unique structure and functional groups.
Used in Polymer Production:
Trans-5-Amino-6-hydroxy-2,2-dimethyl-1,3-dioxacycloheptane is used as a monomer or a component in the production of polymers with specialized properties.
Used in Advanced Materials:
trans-5-Amino-6-hydroxy-2,2-dimethyl-1,3-dioxacyloheptane is employed in the development of advanced materials, potentially due to its unique structural features and the possibility of forming complex molecular arrangements.

InChI:InChI=1/C7H15NO3/c1-7(2)10-3-5(8)6(9)4-11-7/h5-6,9H,3-4,8H2,1-2H3/t5-,6-/m0/s1

Upstream product

• 57280-22-5 4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]-octane 
• 1010702-30-3 (5R,6S)-2,2-dimethyl-6-<(S)-1-phenylmethylamino>-1,3-dioxepan-5-ol 

Relevant articles and documents

Divergent approach to the synthesis of (-)-balanol heterocycle and cis-3-hydroxypipecolic acid based on chiral 2-aminoalkanol equivalent

Enantioselective synthesis of the hexahydroazepine core of (?)-balanol and formal synthesis of cis-3-hydroxypipecolic acid from a common intermediate have been accomplished by a divergent path. The common intermediate was accessed from a favorably protected enantiomerically pure 2-amino-1,3,4-butanetriol (ABT) equivalent via oxidation and Wittig olefination. The synthesis of (?)-balanol heterocycle featured tandem reduction/acetal-deprotection/γ-lactonization reaction and a one-pot azide reduction followed by seven membered aza-heterocycle formation while the route to cis-3-hydroxypipecolic acid highlighted the base induced piperidine ring formation and regioselective benzylidine-acetal cleavage.

ACYCLIC AMINE INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND HYDROLASES

The invention relates to compounds of the general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNPs) and/or nucleoside hydrolases (NHs). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.

Intermediates and synthesis of 2-amino-2-deoxytetritols

Novel methods are provided for synthesizing 2-amino-2-tetritol, by positive halogen addition to protected 1,4-dioxybutene-2 in the presence of a nitrile, resulting in addition of a halo functionality and the nitrile functionality across the double bond. Upon hydrolysis, the desired erythro-product can be obtained in stereochemically good yield.

Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media

Novel intermediates for non-ionic polyiodo amino-substituted benzenepolyamides having polyol substituents on the amide nitrogens are provided which are 5-amino-6-hydroxy-1,3-dioxepanes. The compounds provide an economic and efficient route to novel contrast media having excellent chemical and physiological properties. Also provided are methods for preparing the subject compounds.