cas 80021-38-1, 4-methyl-6-(4-nitrophenyl)-2-pyridinecarboxylic acid

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Antiallergic agents. 2. N-(1H-tetrazol-5-yl)-6-phenyl-2-pyridinecarboxamides
A new series of N-(1H-tetrazol-5-yl)-6-phenyl-2-pyridinecarboxamides was prepared to determine the effects of substituents on the benzene and pyridine rings on antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) assay after oral administr
Honma,Oda,Hashiyama,Hanamoto,Nakai,Inoue,Ishida,Takeda,Ono,Tsuzurahara
p. 1499 - 1504
(2007/10/02)

Pyridinecarboxamide derivatives and process for the preparation thereof
N-(5-Tetrazolyl)-6-phenyl-2-pyridinecarboxamide derivatives of the formula: STR1 wherein R is hydrogen, a halogen, a lower alkyl or a lower alkoxy, and the phenyl ring A is a phenyl having a substituent selected from the group consisting of amino, a mono(lower)alkylamino, a di(lower)alkylamino, or a lower aliphatic acylamino, and a pharmaceutically acceptable salt thereof, and process for the preparation thereof. Said pyridinecarboxamide derivatives have excellent anti-allergic activities even by oral administration and are useful as an anti-allergic medicine.
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(2008/06/13)