AN EFFICIENT SYNTHESIS OF THE ENANTIOMERS OF METHADONE-d10
A reactions sequence is described to prepare the enantiomers of Methadone-d10.The proposed scheme allows to synthesize racemic Methadone-d10 with 14percent overall yield, starting from benzene-d6. (-)-Methadone-d10 hydrochloride is assigned the (R)- absolute configuration on the basis of its ORD curve.
Gerardy, B. M.,Poupaert, J.,Dumont, P.
p. 977 - 980
(2007/10/02)
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