- Intermediate of siponimod and synthesis method thereof
-
The invention relates to a novel intermediate compound (a compound as shown in a formula 2A) of siponimod, a synthesis method of the novel intermediate compound, and a method for synthesizing siponimod by adopting the compound as shown in the formula 2A. Specifically, 3-trifluoromethyl-4-halogenated benzoic acid or 3-trifluoromethyl-4-halogenated toluene is taken as an initial raw material and is subjected to reduction, bromination, coupling, substitution and reduction to obtain a compound as shown in a formula 2A, and R is Boc or Ac.
- -
-
-