Ansamycin antibiotics as free radical scavengers isolated from Streptomyces by using the bactericidal action of the hydroxyl radical
Ansamycin antibiotics (1-4) were isolated from the cultured broth of Streptomyces sp. USF-319 strain as a result of our screening for free radical scavengers. They inhibited the bactericidal effect of the Fenton reagent toward Bacillus subtilis by their radical scavenging activity. Some of them also showed inhibitory activity against lipid peroxidation and lipoxygenases.
New ansamycin derivatives generated by simultaneous mutasynthesis
The conversion from triene- to diene-typed ansamycins is clarified step by step in Streptomyces seoulensis IFB-A01. Such an intertype convertibility is adopted to establish for the first time the simultaneous mutasynthesis of both types of C17-benzene ans
Song, Ya Nan,Jiao, Rui Hua,Zhang, Wen Jing,Zhao, Guo Yan,Dou, Huan,Jiang, Rong,Zhang, Ai Hua,Hou, Ya Yi,Bi, Shu Feng,Ge, Hui Ming,Tan, Ren Xiang
(+)-Mycotrienins I and II: Relative and absolute stereochemistry
The complete relative and absolute stereochemistry of the potent antifungal antibiotics (+)-mycotrienin I and (+)-mycotrienin II have been established by chemical correlation with the antitumor agent (+)-trienomycin A.
(+)-Trienomycins A, B, C, and F and (+)-mycotrienins I and II: Relative and absolute stereochemistry
The complete relative and absolute stereochemistries have been elucidated for the ansamycin antibiotics (+)-trienomycins A, B, and C and their potent antifungal congeners, the (+)-mycotrienins I and II. A new species, (+)-trienomycin F, has also been isol
Smith III, Amos B.,Wood, John L.,Wong, Weichyun,Gould, Alexandra E.,Rizzo, Carmelo J.,Barbosa, Joseph,Komiyama, Kanki,Omura, Satoshi
p. 8308 - 8315
(2007/10/03)
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