- Nickel-Catalyzed Cyanation of Unactivated Alkyl Sulfonates with Zn(CN)2
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Cyanation of unactivated primary and secondary alkyl mesylates with Zn(CN)2 catalyzed by nickel has been developed. The reaction provides an efficient route for the synthesis of alkyl nitriles with wide substrate scope, good functional group tolerance, and compatibility with heterocyclic compounds. Mechanistic studies indicate that alkyl iodide generated in situ serves as the reactive intermediate and the gradual release of alkyl iodide is crucial for the success of the reaction.
- Xia, Aiyou,Lv, Peizhuo,Xie, Xin,Liu, Yuanhong
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supporting information
p. 7842 - 7847
(2020/11/02)
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- A visible-light photoinduced charge-transfer complex promoted the ring opening of: N-alkyl-4-piperidinols
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A visible-light photoinduced ring opening of N-alkyl-4-piperidinols under mild conditions has been achieved. The reaction sequence involves a visible-light-induced charge-transfer complex, which promoted the S-Cl bond cleavage of sulfonyl chlorides. The generated sulfonyl radical further reacts with N-alkyl-4-piperidinol cation radicals to achieve C-N and C-C bond cleavages to yield homoallylamine products.
- Du, Zhengyin,Fu, Ying,Huo, Congde,Shi, Chun-Zhao,Xu, Qin-Shan
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supporting information
p. 2264 - 2269
(2020/04/21)
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- Copper-Catalyzed and Indium-Mediated Methoxycarbonylation of Unactivated Alkyl Iodides with Balloon CO
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This work emphasizes the synthesis of alkyl esters via Cu-catalyzed and In-mediated alkoxycarbonylation of unactivated alkyl iodides in the presence of In or InI. The reactions were suitable for the preparation of primary, secondary, and even tertiary alkyl esters, representing an exceptionally rare example for the creation of quaternary carbon centers upon formation of esters. The preliminary mechanistic studies indicated that alkyl radicals were involved, and Cu/In/CO played a cooperative role in the carbonylation event.
- Chen, Yanchi,Su, Lei,Gong, Hegui
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supporting information
p. 4689 - 4693
(2019/06/27)
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- Visible-Light-Mediated Aerobic Oxidation of Organoboron Compounds Using in Situ Generated Hydrogen Peroxide
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A simple and general visible-light-mediated oxidation of organoboron compounds has been developed with rose bengal as the photocatalyst, substoichiometric Et3N as the electron donor, as well as air as the oxidant. This mild and metal-free protocol shows a broad substrate scope and provides a wide range of aliphatic alcohols and phenols in moderate to excellent yields. Notably, the robustness of this method is demonstrated on the stereospecific aerobic oxidation of organoboron compounds.
- Weng, Wei-Zhi,Liang, Hao,Zhang, Bo
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supporting information
p. 4979 - 4983
(2018/08/24)
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- PTAB mediated open air synthesis of sulfonamides, thiosulfonates and symmetrical disulfanes
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A facile methodology has been described which has successfully simplified the generation of sulfonamides, thiosulfonates and symmetric disulfanes. This “trio” of reactions occur in an open air metal free atmosphere and has also been scaled up to grams making it suitable for commercialization. The reactions also have been successfully carried out with asymmetric variants, thus contributing to the chiral pool. The user friendly “trio” enables easy generation of these versatile sulfur analogues and the reaction condition employed depict an economic outline.
- Sarkar, Debayan,Ghosh, Manoj Kumar,Rout, Nilendri
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supporting information
p. 2360 - 2364
(2018/05/24)
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- Radical Deuteration with D2O: Catalysis and Mechanistic Insights
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Selective incorporation of deuterium atoms into molecules is of high interest for labeling purposes and for optimizing properties of drug candidates. A mild and environmentally benign method for the deuteration of alkyl iodides via radical pathway using D2O as source of deuterium has been developed. The reaction is initiated and mediated by triethylborane in the presence of dodecanethiol as a catalyst. This method is compatible with a wide range of functional groups and provides the monodeuterated products in good yields and with a high level of deuterium incorporation. It opens promising opportunities for the development of enantioselective radical reactions. Moreover, a revision of the mechanism of the deoxygenation reaction of xanthates using R3B and water (Wood deoxygenation) is presented.
- Soulard, Valentin,Villa, Giorgio,Vollmar, Denis Patrick,Renaud, Philippe
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supporting information
p. 155 - 158
(2018/01/17)
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- Palladium and visible-light mediated carbonylative Suzuki-Miyaura coupling of unactivated alkyl halides and aryl boronic acids
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Herein, a simple and efficient method for the palladium-catalyzed carbonylation of aryl boronic acids with unactivated alkyl iodides and bromides under visible-light irradiation, ambient temperature and low CO-pressure is presented. Notably, the procedure uses readily available equipment and an inexpensive palladium catalyst to generate the key alkyl radical intermediate. These mild conditions enabled the synthesis of a range of functionalized aryl alkyl ketones including the antipsychotic drug, melperone.
- Roslin, Sara,Odell, Luke R.
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supporting information
p. 6895 - 6898
(2017/07/10)
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- Synthesis of Pyrrolidines and Pyrrolizidines with α-Pseudoquaternary Centers by Copper-Catalyzed Condensation of α-Diazodicarbonyl Compounds and Aryl γ-Lactams
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N-aryl γ-lactams react intermolecularly with acceptor–acceptor diazo reagents, usually dicarbonyl compounds, in a copper-catalyzed process to yield functionalized pyrrolidines with α-pseudoquaternary centers. As 1,2-acyl or -phosphoryl migration is prefer
- Goudedranche, Sébastien,Besnard, Céline,Egger, Léo,Lacour, Jér?me
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supporting information
p. 13775 - 13779
(2016/10/26)
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- Cobalt-Catalyzed Cross-Coupling of 3- and 4-Iodopiperidines with Grignard Reagents
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A cobalt-catalyzed cross-coupling between 3- and 4-iodopiperidines and Grignard reagents is disclosed. The reaction is an efficient, cheap, chemoselective, and flexible way to functionalize piperidines. This coupling was used as the key step to realize a short synthesis of (±)-preclamol. Some mechanistic investigations were conducted that highlight the formation of radical intermediates. Scaffold synthesis: A cobalt-catalyzed cross-coupling between iodopiperidines and Grignard reagents is reported (see scheme; PG=protecting group). A large variety of 3- and 4-substituted piperidines were synthesized and the method was applied to a short synthesis of (±)-preclamol. This work constitutes one of the rare examples of cross-couplings involving 3-halogeno piperidines.
- Gonnard, Laurine,Gurinot, Amandine,Cossy, Janine
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supporting information
p. 12797 - 12803
(2015/09/01)
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- Iron- and cobalt-catalyzed arylation of azetidines, pyrrolidines, and piperidines with grignard reagents
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Iron- and cobalt-catalyzed cross-couplings between iodo-azetidines, -pyrrolidines, -piperidines, and Grignard reagents are disclosed. The reaction is efficient, cheap, chemoselective and tolerates a large variety of (hetero)aryl Grignard reagents.
- Barr, Baptiste,Gonnard, Laurine,Campagne, Rmy,Reymond, Sbastien,Marin, Julien,Ciapetti, Paola,Brellier, Marie,Gurinot, Amandine,Cossy, Janine
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supporting information
p. 6160 - 6163
(2015/01/16)
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- Palladium-catalyzed heck-type cross-couplings of unactivated alkyl iodides
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A palladium-catalyzed, intermolecular Heck-type coupling of alkyl iodides and alkenes is described. This process is successful with a variety of primary and secondary unactivated alkyl iodides as reaction partners, including those with hydrogen atoms in t
- McMahon, Caitlin M.,Alexanian, Erik J.
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supporting information
p. 5974 - 5977
(2014/06/10)
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- 11-BETA HSD1 INHIBITORS
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This invention relates to inhibiting 11βHSD1.
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Page/Page column 132-133
(2008/06/13)
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- New synthesis of 3-arylpyrrolines
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We present an easy and straightforward synthesis of 3-arylpyrrolines 4a-g by repeated treatment of 4-aryl-1,2,5,6-tetrahydropyridines 2a-g with m-chloroperoxybenzoic acid (MCPBA) and boron trifluoride etherate (BF 3-OEt2). The transformation proceeds via epoxidation, ring contraction, Baeyer-Villiger oxidation and elimination reaction and affords 3-arylpyrrolines 4a-g with 61-70% yield. This facile strategy was also used to synthesize racemic baclofen (6).
- Chang, Meng-Yang,Pai, Chun-Li,Kung, Yung-Hua
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p. 855 - 859
(2007/10/03)
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- CAN-mediated oxidative cleavage of 4-aryl-3,4-dihydroxypiperidines
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A CAN-mediated oxidative cleavage of 4-aryl-3,4-dihydroxypiperidines 2Aa-Be to β-amino carbonyl compounds 3Aa-Be and 4Aa-Be in different ratios is described. This facile strategy was also used to synthesize racemic fluoxetine (5).
- Chang, Meng-Yang,Lin, Chun-Yu,Pai, Chun-Li
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p. 2565 - 2568
(2007/10/03)
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- Facile and Clean Oxidation of Alcohols in Water Using Hypervalent Iodine (III) Reagents
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The facile and efficient oxidation of various alcohols such as benzylic alcohols, primary alcohols, secondary alcohols, and diols in water using the hypervalent iodine(III) reagent, iodosobenzene (PhI=O), with KBr is described. Electrospray ionization (ESI) mass spectrometric studies on the behavior of PhI=O-KBr in aqueous solution suggested that these reactions are induced by the formation of highly reactive iodine species [PhI(Br)nO-]. Further development to recyclable polymer-supported iodine(III) reagent extends the utility of this reaction to afford an environmentally benign method.
- Tohma, Hirofumi,Maegawa, Tomohiro,Takizawa, Shinobu,Kita, Yasuyuki
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p. 328 - 337
(2007/10/03)
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