802306-26-9Relevant articles and documents
Diselenides and benzisoselenazolones as antiproliferative agents and glutathione-S-transferase inhibitors
Krasowska, Dorota,Iraci, Nunzio,Santi, Claudio,Drabowicz, Józef,Cieslak, Marcin,Ka?mierczak-Barańska, Julia,Palomba, Martina,Królewska-Golińska, Karolina,Magiera, Jakub,Sancineto, Luca
, (2019/08/20)
A series of variously functionalized selenium-containing compounds were purposely synthesized and evaluated against a panel of cancer cell lines. Most of the compounds showed an interesting cytotoxicity profile with compound 5 showing a potent activity on MCF7 cells. The ethyl amino derivative 5 acts synergistically with cis-platin and inhibits the GST enzyme with a potency that well correlates with the cytotoxicity observed in MCF7 cells. A computational analysis suggests a possible binding mode on the GST enzyme. As the main outcome of the present study, the ethyl amino derivative 5 emerged as a valid lead compound for further, future developments.
Homoleptic organometallic compounds of heavy pnicogens. Crystal and molecular structure of [2-(iPr2NCH2)C6H4]3M (M = Sb, Bi)
Chirc?, Ion,Soran, Albert,Silvestru, Anca,Silvestru, Cristian
, p. 643 - 650 (2015/11/24)
Two new homoleptic triorganopnicogen(III) species, [2-(iPr2NCH2)C6H4]3M [M = Sb (2), Bi (3)] were obtained by reacting [2-(iPr2NCH2)C6H4/su
Reduction of base-stabilized difluoroboranes to induce rearrangement reactions
Yamashita, Makoto,Aramaki, Yoshitaka,Nozaki, Kyoko
experimental part, p. 1774 - 1782 (2011/01/11)
Lewis base-stabilized difluoroboranes 2, 4-pyr and 4-iPr, having an oxazoline- or amine-tethered amide ligand, were synthesized and fully characterized. The treatment of 2 with KC8 led to its complete consumption, and the rearranged
