- Oxy-polybrominated diphenyl ethers from the indonesian marine sponge, lamellodysidea herbacea: X-ray, sar, and computational studies
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Polybrominated diphenyl ether (PBDE) compounds, derived from marine organisms, originate from symbiosis between marine sponges and cyanobacteria or bacteria. PBDEs have broad biological spectra; therefore, we analyzed structure and activity relationships of PBDEs to determine their potential as anticancer or antibacterial lead structures, through reactions and computational studies. Six known PBDEs (1–6) were isolated from the sponge, Lamellodysdiea herbacea;13C NMR data for compound 6 are reported for the first time and their assignments are confirmed by their theoretical13C NMR chemical shifts (RMSE ′, 5′-dibromo-2′-hydroxyphenoxy) phenol) at the phenol functional group gave seven molecules (7–13), of which 10, 12, and 13 were new. New crystal structures for 8 and 9 are also reported. Debromination carried out on 1 produced nine compounds (1, 2, 14, 16–18, 20, 23, and 26) of which 18 was new. Debromination product 16 showed a significant IC50 8.65 ± 1.11; 8.11 ± 1.43 μM against human embryonic kidney (HEK293T) cells. Compounds 1 and 16 exhibited antibacterial activity against Gram-positive Staphylococcus aureus and Gram-negative Klebsiella pneumoniae with MID 0.078 μg/disk. The number of four bromine atoms and two phenol functional groups are important for antibacterial activity (S. aureus and K. pneumoniae) and cytotoxicity (HEK293T). The result was supported by analysis of frontier molecular orbitals (FMOs). We also propose possible products of acetylation and debromination using analysis of FMOs and electrostatic charges and we confirm the experimental result.
- Dinelsa, Fabians Faisal,Farid, Muhamad,Hanif, Novriyandi,Hidayati, Lestari,Khalik, Gibral Abdul,Kinnary, Nyimas Ratna,Kurnianda, Viqqi,Mubarok, Zaki,Murni, Anggia,Prasetiawan, Fauzi Muhamad,Provita, Dian,Setiawan, Andi,Tanaka, Junichi,Tohir, Dudi,Tyas, Trianda Ayuning,de Voogd, Nicole J.
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- Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea
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Four new (1-4) and 10 known polybrominated diphenyl ethers (5-14) have been isolated from the title sponge. The structures of the new entities were elucidated by interpretation of spectroscopic data and chemical transformations. These metabolites showed p
- Hanif, Novriyandi,Tanaka, Junichi,Setiawan, Andi,Trianto, Agus,De Voogd, Nicole J.,Murni, Anggia,Tanaka, Chiaki,Higa, Tatsuo
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p. 432 - 435
(2008/02/03)
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- Antibacterial compounds and uses thereof
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The invention relates to antibacterial compounds and their use to treat bacterial infections. More particularly, the invention relates to substituted biphenyl compounds having antibacterial activity. The invention provides methods for treating bacterial infections using PBDEs that have not previously been used to treat bacterial infections. The invention further provides novel PBDEs that are useful in such methods.
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Page/Page column 9-10
(2008/06/13)
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