A robust multifunctional ligand-controlled palladium-catalyzed carbonylation reaction in water
A novel, hydrophilic and recyclable methoxypolyethylene glycol (PEG)-modulated s-triazine-based multifunctional Schiff base/N,P-ligand L9 was prepared and used in Pd-catalyzed Heck-type carbonylative coupling reactions, affording diverse chalcone derivatives and 1,4-dicarbonyl esters in good yields.
Aglycone exploration of C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2
Inhibition of sodium-dependent glucose transporter 2 (SGLT2), the transporter that is responsible for renal re-uptake of glucose, leads to glucosuria in animals. SGLT-mediated glucosuria provides a mechanism to shed excess plasma glucose to ameliorate dia
Ellsworth, Bruce A.,Meng, Wei,Patel, Manorama,Girotra, Ravindar N.,Wu, Gang,Sher, Philip M.,Hagan, Deborah L.,Obermeier, Mary T.,Humphreys, William G.,Robertson, James G.,Wang, Aiying,Han, Songping,Waldron, Thomas L.,Morgan, Nathan N.,Whaley, Jean M.,Washburn, William N.
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p. 4770 - 4773
(2009/05/07)
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