A Series of 2-((1-Phenyl-1H-imidazol-5-yl)methyl)-1H-indoles as Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors
Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising therapeutic target in cancer immunotherapy and neurological disease. Thus, searching for highly active inhibitors for use in human cancers is now a focus of widespread research and development efforts. I
Zheng, Yong,Stafford, Paul M.,Stover, Kurt R.,Mohan, Darapaneni Chandra,Gupta, Mayuri,Keske, Eric C.,Schiavini, Paolo,Villar, Laura,Wu, Fan,Kreft, Alexander,Thomas, Kiersten,Raaphorst, Elana,Pasangulapati, Jagadeesh P.,Alla, Siva R.,Sharma, Simmi,Mittapalli, Ramana R.,Sagamanova, Irina,Johnson, Shea L.,Reed, Mark A.,Weaver, Donald F.
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p. 2195 - 2205
(2021/05/31)
Process for the production of hydroxymethylimidazoles
This invention discloses a process for the production of hydroxymethylimidazoles which comprises reacting imidazolecarboxylic acids, their esters or inorganic salts with a formaldehyde agent in the presence of an alkali in an aqueous medium.
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(2008/06/13)
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