Titanium(IV) isopropoxide mediated synthesis of pyrimidin-4-ones
A novel, one-step method for the synthesis of tri- and tetrasubstituted pyrimidin-4-ones is reported. This method involves a titanium(IV)-mediated cyclization involving two sequential condensations of primary and β-ketoamides. The reaction is operationally facile, readily scalable, and offers rapid entry into differentially substituted pyrimidin-4-one scaffolds. The high functional group compatibility allows for substantial diversification in the products generated from this transformation.
Ramanjulu, Joshi M.,Demartino, Michael P.,Lan, Yunfeng,Marquis, Robert
supporting information; experimental part
p. 2270 - 2273
(2010/07/17)
A facile synthesis of 4(3H)-pyrimidinones via [4 + 2] cycloaddition utilizing trimethylsilylketene
The [4+2]cycloaddition reaction utilizing trimethylsilylketene with 1,3-diaza-1,3-dienes smoothly proceeded to give the desired cycloadducts, 4(3H)-pyrimidinones, in moderate to high yields.