Nitrogen-containing bicyclic compounds and preparation method and use thereof
The present invention relates to nitrogen-containing bicyclic compounds and a preparation method and use thereof. The compounds or pharmaceutical compositions can be used as an inhibitor of retinoic acid-related orphan receptor gamma t (ROR gamma t). The invention also relates to the preparation method of the compounds and pharmaceutical compositions, and use of the in the compounds and pharmaceutical compositions in treatment or prevention of RORyt-mediated inflammatation or autoimmune diseases in mammals, particularly humans.
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Paragraph 0658; 0660-0661
(2018/11/04)
Aryl alkynyl hydrocarbon compound and preparation method and application thereof
The invention relates to an aryl alkynyl hydrocarbon compound and a medicine compound containing the compound. The compound or the medicine compound can serve as an inhibitor of Retinoid-related orphan receptor gamma t (RORyt). The invention further relates to a method for preparing the compound and the medicine compound and application thereof to mammal treatment or prevention, especially RORyt mediated inflammation of humans or autoimmune diseases.
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Paragraph 0492; 0493
(2017/02/17)
NEW P2X7 RECEPTOR ANTAGONISTS AND THEIR USE
The invention provides compounds of formula (IA), processes for their preparation, pharmaceutical compositions containing them, and their use in therapy. [Chemical formula should be inserted here. Please see paper copy] (IA)
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Page 76-77
(2008/06/13)
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