Synthesis and Biological Activities of 4-Arylformamidinothiosemicarbazone and 1,2,4-Thiadiazole Derivatives
Two new series of 4-arylformamidinothiosemicarbazones (II) and 3-arylamino-5-alkylidene/arylidene-hydrazino-1,2,4-thiadiazoles (VI) have been synthesised and screened for local anaesthetic, antifungal, larvicidal and insecticidal activities.The compounds with p-Cl, p-ethoxy or p-methoxy substituent in the phenyl ring show higher potency in both local anaesthetic and antifungal tests.None of the compounds exhibits any larvicidal or insecticidal activity.
Pandeya, S. N.,Ram, P.
p. 825 - 827
(2007/10/02)
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