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3-[BIS(PHENYLMETHOXY)PHOSPHINYL]-PR
OPANOIC ACID is a chemical compound characterized by a propanoic acid backbone with phosphorus and phenyl groups attached. It is known for its role as a ligand in organometallic chemistry and catalysis reactions, where it coordinates with metal ions to facilitate a range of chemical transformations. The bis(phenylmethoxy)phosphinyl groups enhance the compound's stability and reactivity, making it a valuable asset in synthetic chemistry and various industrial processes. Furthermore, its unique structural properties and versatility in chemical reactions have garnered interest in pharmaceutical and material science research.

805243-04-3

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805243-04-3 Usage

Uses

Used in Organometallic Chemistry:
3-[BIS(PHENYLMETHOXY)PHOSPHINYL]-PR
OPANOIC ACID is used as a ligand for its ability to coordinate with metal ions, which is crucial in organometallic chemistry for stabilizing metal complexes and enabling specific chemical reactions.
Used in Catalysis Reactions:
In catalysis, 3-[BIS(PHENYLMETHOXY)PHOSPHINYL]-PR
OPANOIC ACID serves as a ligand to facilitate various chemical transformations, enhancing the efficiency and selectivity of the reactions.
Used in Pharmaceutical Research:
3-[BIS(PHENYLMETHOXY)PHOSPHINYL]-PR
OPANOIC ACID is utilized in pharmaceutical research for its potential applications in drug development, given its unique structural properties and ability to participate in a wide array of chemical reactions.
Used in Material Science Research:
3-[BIS(PHENYLMETHOXY)PHOSPHINYL]-PR
OPANOIC ACID is also used in material science research, where its versatility and reactivity can contribute to the development of new materials with specific properties.
Used in Industrial Processes:
3-[BIS(PHENYLMETHOXY)PHOSPHINYL]-PR
OPANOIC ACID is employed in various industrial processes, leveraging its stability and reactivity to improve the synthesis of complex organic compounds and other chemical products.

Check Digit Verification of cas no

The CAS Registry Mumber 805243-04-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,0,5,2,4 and 3 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 805243-04:
(8*8)+(7*0)+(6*5)+(5*2)+(4*4)+(3*3)+(2*0)+(1*4)=133
133 % 10 = 3
So 805243-04-3 is a valid CAS Registry Number.

805243-04-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-bis(phenylmethoxy)phosphorylpropanoic acid

1.2 Other means of identification

Product number -
Other names Propanoic acid,3-[bis(phenylmethoxy)phosphinyl]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:805243-04-3 SDS

805243-04-3Downstream Products

805243-04-3Relevant articles and documents

Live-Cell Protein Modification by Boronate-Assisted Hydroxamic Acid Catalysis

Adamson, Christopher,Kajino, Hidetoshi,Kanai, Motomu,Kawashima, Shigehiro A.,Yamatsugu, Kenzo

supporting information, p. 14976 - 14980 (2021/09/29)

Selective methods for introducing protein post-translational modifications (PTMs) within living cells have proven valuable for interrogating their biological function. In contrast to enzymatic methods, abiotic catalysis should offer access to diverse and new-to-nature PTMs. Herein, we report the boronate-assisted hydroxamic acid (BAHA) catalyst system, which comprises a protein ligand, a hydroxamic acid Lewis base, and a diol moiety. In concert with a boronic acid-bearing acyl donor, our catalyst leverages a local molarity effect to promote acyl transfer to a target lysine residue. Our catalyst system employs micromolar reagent concentrations and affords minimal off-target protein reactivity. Critically, BAHA is resistant to glutathione, a metabolite which has hampered many efforts toward abiotic chemistry within living cells. To showcase this methodology, we installed a variety of acyl groups inE. colidihydrofolate reductase expressed within human cells. Our results further establish the well-known boronic acid-diol complexation as abona fidebio-orthogonal reaction with applications in chemical biology and in-cell catalysis.

Isoprenoid biosynthesis via the methylerythritol phosphate pathway: Structural variations around phosphonate anchor and spacer of fosmidomycin, a potent inhibitor of deoxyxylulose phosphate reductoisomerase

Zingle, Catherine,Kuntz, Lionel,Tritsch, Denis,Grosdemange-Billiard, Catherine,Rohmer, Michel

supporting information; experimental part, p. 3203 - 3207 (2010/08/19)

Fosmidomycin and its analogue FR-900098 are potent inhibitors of 1-deoxy-d-xylulose 5-phosphate reducto-isomerase (DXR), the second enzyme of the MEP pathway for the biosynthesis of isoprenoids. This paper describes the synthesis of analogues of the two reverse phosphonohydroxamic acids 3 and 4, in which the length of the carbon spacer is modified, the N-methyl group of 3 is replaced by an ethyl group, and the phosphate group is replaced by potential isosteric moieties, i.e., sulfonate or carboxylate functionalities. The potential of the synthesized analogues to inhibit the E. coli DXR was evaluated.

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