cas 80568-96-3, 5-M-TOLYL-2H-PYRAZOL-3-YLAMINE

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80568-96-3

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Polysubstituted heterocyclic derivative, preparation method thereof and application of polysubstituted heterocyclic derivative in medicine
The invention provides a polysubstituted heterocyclic derivative, a preparation method thereof and application of the polysubstituted heterocyclic derivative in medicine, and belongs to the technical field of medicinal chemistry. The polysubstituted heterocyclic derivative is a compound shown in a general formula I or II, a pharmaceutically acceptable salt or a solvate of the compound, and the compound can inhibit mRNA demethylase on the protease level and is used for treating diseases related to mRNA demethylase functions.
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Paragraph 0035-0037; 0053; 0057-0058; 0351; 0355-0356

(2021/06/02)

A new, one-pot, multicomponent synthesis of 5-aza-9-deaza-adenines under microwave irradiation
A new, practical, three-component method for the synthesis of 5-aza-9-deaza-adenines is developed. Aminopyrazoles react in a one-pot fashion with triethyl orthoformate and cyanamide under microwave irradiation affording 5-aza-9-deaza-adenines in good yiel
Lim, Felicia Phei Lin,Luna, Giuseppe,Dolzhenko, Anton V.
p. 5159 - 5163
(2014/12/10)

Novel potent neuropeptide Y Y5 receptor antagonists: Synthesis and structure-activity relationships of phenylpiperazine derivatives
A series of phenylpiperazine derivatives were synthesized and evaluated for their neuropeptide Y (NPY) Y5 receptor antagonistic activities. The benzindane portion of 2 was replaced by 1-phenylpiperazine, resulting in novel urea derivative 3f. Subsequent optimization of the phenylpiperazine template by substitution of the phenyl moiety resulted in a series of (2-methanesulfonamidephenyl)piperazine derivatives that showed potent binding affinity and antagonistic activity for the Y5 receptor.
Takahashi, Toshiyuki,Sakuraba, Aya,Hirohashi, Tomoko,Shibata, Takunobu,Hirose, Masaaki,Haga, Yuji,Nonoshita, Katsumasa,Kanno, Tetsuya,Ito, Junko,Iwaasa, Hisashi,Kanatani, Akio,Fukami, Takehiro,Sato, Nagaaki
p. 7501 - 7511
(2007/10/03)

Chemical Properties

Melting Point: 86-89°C
Boiling Point: 430.24 °C at 760 mmHg
Flash Point:243.84 °C
Density: 1.196 g/cm³
Storage Temp.:Sealed in dry,Room Temperature
Vapor Pressure: 1.32E-07mmHg at 25°C
Refractive Index: 1.643
PSA: 54.70000
LogP: 2.54850

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80568-96-3

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Chemical Properties

Melting Point: 86-89°C

Boiling Point: 430.24 °C at 760 mmHg

Flash Point:243.84 °C

Density: 1.196 g/cm³

Storage Temp.:Sealed in dry,Room Temperature

Vapor Pressure: 1.32E-07mmHg at 25°C

Refractive Index: 1.643

PSA: 54.70000

LogP: 2.54850

Global suppliers and manufacturers of 80568-96-3total 12 suppliers on LookChem

Article Database

80568-96-3

Articles about 80568-96-3Total 3 be found

More Articles about upstream products of 80568-96-3

More Articles about downstream products of 80568-96-3

Chemical Properties

Melting Point: 86-89°C

Boiling Point: 430.24 °C at 760 mmHg

Flash Point:243.84 °C

Density: 1.196 g/cm3

Storage Temp.:Sealed in dry,Room Temperature

Vapor Pressure: 1.32E-07mmHg at 25°C

Refractive Index: 1.643

PSA: 54.70000

LogP: 2.54850

Global suppliers and manufacturers of 80568-96-3total 12 suppliers on LookChem

Density: 1.196 g/cm³