807343-03-9

Basic information

• Product Name: N-(2-chlorobenzyl)-N-propylamine
• Synonyms: N-(2-chlorobenzyl)-N-propylamine;(2-CHLOROBENZYL)PROPYLAMINE;N-(2-CHLOROPHENYLMETHYL)PROPYLAMINE;UKRORGSYN-BB BBV-077905;(2-chlorobenzyl)propylamine(SALTDATA: HCl);N-(2-Chlorobenzyl)propan-1-aMine;[(2-chlorophenyl)methyl](propyl)amine hydrochloride
• CAS NO: 807343-03-9
• Molecular Formula: C₁₀H₁₄ClN
• Molecular Weight: 183.68
• Mol File: 807343-03-9.mol

Chemical Properties

• Boiling Point: 245.8°C at 760 mmHg
• Flash Point: 102.4°C
• Appearance: /
• Density: 1.043g/cm³
• Vapor Pressure: 0.0282mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: N-(2-chlorobenzyl)-N-propylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-chlorobenzyl)-N-propylamine(807343-03-9)
• EPA Substance Registry System: N-(2-chlorobenzyl)-N-propylamine(807343-03-9)

Safety Data

• Hazardous Substances Data: 807343-03-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
N-(2-chlorobenzyl)-N-propylamine is used as a reagent for the synthesis of N-(substituted benzyl)-N-propyl-2-(trichloromethyl) quinazolin-4-amine derivatives. These derivatives have been evaluated for their cytotoxic properties, making them potential candidates for the development of new anticancer drugs.
In the pharmaceutical industry, N-(2-chlorobenzyl)-N-propylamine plays a crucial role in the development of novel therapeutic agents, particularly in the area of oncology. Its unique chemical structure allows for the creation of cytotoxic compounds that can target and eliminate cancer cells, offering hope for improved cancer treatments in the future.

InChI:InChI=1/C10H14ClN/c1-2-7-12-8-9-5-3-4-6-10(9)11/h3-6,12H,2,7-8H2,1H3

Upstream product

• 107-10-8 propylamine 
• 89-98-5 2-chloro-benzaldehyde 
• 58645-99-1 1-(2-chlorophenyl)-N-propylmethanimine 

Downstream Products

• 55245-91-5 C₁₁H₁₃Cl₂NO 

Relevant articles and documents

Synthesis and biological activity of some novel substituted quinazoline derivatives

A new series of 4-N-(substituted benzyl)-2-phenyl-N-propylquinazolines were synthesized. The structures of the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis. All the synthesized compounds were screened for their analgesic and anti-inflammatory activity. Among the synthesized compounds 5c, 5h and 5o exhibited significant analgesic activity at 60 and 90 minutes reading, while compounds 5g, 5k and 5l exhibited significant anti-inflammatory activity at 3rd and 4th hr reading.

TACHYKININ RECEPTOR ANTAGONISTS

The present invention relates to selective NK-1 receptor antagonists of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins.

Preparation of benzolactams by Pd(OAC)2-catalyzed direct aromatic carbonylation

We developed a new method for Pd(II)-catalyzed direct aromatic carbonylation in a phosphine-free catalytic system using Pd(OAc)2 and Cu(OAc)2 in an atmosphere of CO gas containing air. The carbonylation proceeded with ortho-palladation, inducing a remarkable site selectivity to afford a variety of five- or six-membered benzolactams from secondary ω-arylalkylamines, such as N-alkylbenzylamines or N-alkylphenethylamines. Copyright