- COMPOUNDS FOR THE TREATMENT OF AMYLOID-ASSOCIATED DISEASES
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This invention provides novel compounds of formulae (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein the substituents are as defined in the specification. The present invention also relates to the novel compounds for use as a medicine, more in particular for the prevention or treatment of amyloid-related diseases, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, disorders characterized by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such amyloid-related diseases. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.
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Page/Page column 183
(2016/06/14)
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- 2-ARYL AND 2-HETEROARYL 4H-1-BENZOPYRAN-4-ONE-6-AMIDINO DERIVATIVES, NEW PHARMACOLOGICAL AGENTS FOR THE TREATMENT OF ARTHRITIS, CANCER AND RELATED PAIN
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2-aryl and 2-heteroaryl 4h-1-benzopyran-4-one-6-amidino derivatives of formula (I) useful as pharmacological agents for the treatment of arthritis, cancer and related pain.
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Page/Page column 10
(2011/01/12)
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- Synthesis and complete assignment of the 1H and 13C NMR signals of new acetamido and aminoflavonoid derivatives
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The complete 1H and13C NMR assignment of 9 acetamidochalcones, 18 acetamidoflavones, 18 aminoflavones, 9 acetamidoflavonols and 9 aminoflavonols has been performed using one- and two-dimensional NMR techniques including COSY, HMQC and HMBC experiments. Copyright
- Casano, Gilles,Robin, Maxime,Barbier, Pascale,Peyrotb, Vincent,Faurea, Robert
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experimental part
p. 738 - 744
(2011/05/02)
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- Anti-HIV and antiplasmodial activity of original flavonoid derivatives
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In our search for potent anti-HIV and antiplasmodial agents, novel series of flavonoid derivatives and their chalcone intermediates were synthesized and evaluated for inhibition of HIV multiplication and antiproliferative activity on Plasmodium falciparum
- Casano, Gilles,Dumtre, Aurélien,Pannecouque, Christophe,Hutter, Sébastien,Azas, Nadine,Robin, Maxime
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experimental part
p. 6012 - 6023
(2010/10/02)
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- 2-ARYL AND 2 -HETEROARYL 4H-1-BENZOPYRAN-4-ONE-6-AMIDINO DERIVATIVES FOR THE TREATMENT OF ARTHRITIS, CANCER AND RELATED PAIN
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2-aryl and 2-heteroaryl 4h-1-benzopyran-4-one-6-amidino derivatives of formula (I) useful as pharmacological agents for the treatment of arthritis, cancer and related pain.
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Page/Page column 17
(2009/10/22)
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