- On the mechanism of Ni(II)-promoted Michael-type hydroamination of acrylonitrile and its substituted derivatives
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Michael-type hydroamination of acrylonitrile and its substituted derivatives promoted by Ni(ii) complexes is believed to proceed via an outer-sphere nucleophilic attack on the cationic adduct of the nitrile-coordinated substrate. As a test for the validit
- Lapointe,Zargarian
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- Asymmetric catalytic hydroamination of activated olefins in ionic liquids
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The addition of a series of both aliphatic and aromatic amines to electron-poor olefins was investigated using [Ni(Pigiphos)(THF)]2- as catalyst (with different counterions) in various ionic liquids based on imidazolium- and picolinium-salt der
- Fadini, Luca,Togni, Antonio
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p. 411 - 424
(2008/02/08)
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- Anti-Markovnikov N-H and O-H additions to electron-deficient olefins catalyzed by well-defined Cu(I) anilido, ethoxide, and phenoxide systems
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The monomeric Cu(I) complexes (IPr)Cu(Z) (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene, Z = NHPh, OEt, or OPh) react with YH (Y = PhNH, PhCH2NH, EtO, or PhO) to catalytically add Y-H bonds across the C=C bond of electron-deficient olefins to yield anti-Markovnikov organic products. Catalytic activity has been observed for olefins CH2C(H)(X) with X = CN, C(O)Me, or CO2Me as well as crotononitrile. Preliminary studies implicate an intermediate in which the C-Y bond forms through a nucleophilic addition pathway. Copyright
- Munro-Leighton, Colleen,Blue, Elizabeth D.,Gunnoe, T. Brent
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p. 1446 - 1447
(2007/10/03)
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- Transition metal-catalyzed process for addition of amines to carbon-carbon double bonds
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The present invention is directed to a process for addition of amines to carbon-carbon double bonds in a substrate, comprising: reacting an amine with a compound containing at least one carbon-carbon double bond in the presence a transition metal catalyst under reaction conditions effective to form a product having a covalent bond between the amine and a carbon atom of the former carbon-carbon double bond. The transition metal catalyst comprises a Group 8 metal and a ligand containing one or more 2-electron donor atoms. The present invention is also directed to enantioselective reactions of amine compounds with compounds containing carbon-carbon double bonds, and a calorimetric assay to evaluate potential catalysts in these reactions.
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Page column 29
(2008/06/13)
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- Ring Opening Reaction of 3,6-Dihydro-2-(1H)pyrimidinones with Hydroxylamine Hydrochloride
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1,4,6-Trisubstituted 3,6-dihydro-2-(1H)pyrimidinones (Ia-d) easily underwent the ring opening reaction with hydroxylamine hydrochloride to afford the oximes (IIa-d) in good yields.In the case of 3,6-dihydro-6-methyl-1-phenyl-2-(1H)pyrimidinone (Ie), 2-anilinobutyronitrile (III) was obtained in addition to the oxime (IIe).Dihydro-2-(1H)pyrimidinone (IV) and -thiones (V and VI) did not undergo the ring opening reaction.
- Kashima, Choji,Katoh, Akira,Yokota, Yuko,Omote, Yoshimori
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p. 1469 - 1470
(2007/10/02)
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