Irreversible Enzyme Inhibitors. 202. Candidate Active-Site-Directed Irreversible Inhibitors of 5-Fluoro-2'-deoxyuridine Phosphorylase from Walker 256 Rat Tumor Derived from 1-Benzyl-5-(3-ethoxybenzyl)uracil
Six candidate irreversible inhibitors of uridine-deoxyuridine phosphorylase (EC 2.4.2.3) from Walker 256 rat tumor were synthesized.These compounds connect a terminal sulfonyl fluoride group to the 1-benzyl moiety of 1-benzyl-5-(3-ethoxybenzyl)uracil (9).
Kelley, James L.,Baker, B. R.
p. 600 - 603
(2007/10/02)
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