- Acrylonitrile compounds
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The present invention relates to acrylonitrile compounds of formula (1): [wherein, R is a C1-C6alkyl, a C3-C7cycloalkyl optionally substituted by a C1-C4alkyl, a naphthyl, etc., R1/su
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Page/Page column 49
(2010/01/31)
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- 1,2,3-Triazoles produced from 5-Substituted N-Methoxytriazolium Salts
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Five reactions, two of which are new, have been observed when 5-substituted 1-methoxy-2-phenyltriazolium salts react with nucleophiles: (i) addition to C-4 with elimination of methanol to give unsymmetrically 4,5-disubstituted triazoles; (ii) displacement of the 5-substituent followed by secondary reactions to give a symmetrically 4,5-disubstituted triazole, a 5-substituted triazole N-oxide, a 4-substituted triazole, or a disubstituted benzeneazoacetonitrile; (iii) deprotonation of the N-methoxy-group with elimination of formaldehyde; (iv) demethylation; (v) abstraction of an α-proton from a 5-alkyl group followed by nucleophilic addition and elimination of methanol to give an α-substituted 5-alkyltriazole.The reactions are of synthetic potential as a means of introducing one or two substituents in the 1,2,3-triazole system.
- Begtrup, Mikael
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p. 2749 - 2756
(2007/10/02)
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