81-90-3

Basic information

• Product Name: PHENOLPHTHALIN
• Synonyms: PHENOLTHALEIN;PHENOLPHTHALIN;2-[bis(4-hydroxyphenyl)methyl]-benzoicaci;LABOTEST-BB LT00772253;alpha,alpha-bis(4-hydroxyphenyl)-o-toluic acid;PHENOLPHTHALIN,98%;Phenolphthalin, pure, 98%;Benzoic acid, 2-bis(4-hydroxyphenyl)methyl-
• CAS NO: 81-90-3
• Molecular Formula: C₂₀H₁₆O₄
• Molecular Weight: 320.34
• EINECS: 201-384-4
• Mol File: 81-90-3.mol

Chemical Properties

• Melting Point: 238 °C
• Boiling Point: 419.24°C (rough estimate)
• Flash Point: 299.7 °C
• Appearance: white glistening fine crystalline powder
• Density: 1.1863 (rough estimate)
• Vapor Pressure: 7.12E-13mmHg at 25°C
• Refractive Index: 1.5400 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: almost transparency in EtOH95vol%
• PKA: 3.96±0.36(Predicted)
• Water Solubility: 175mg/L(20 oC)
• Merck: 14,7244
• CAS DataBase Reference: PHENOLPHTHALIN(CAS DataBase Reference)
• NIST Chemistry Reference: PHENOLPHTHALIN(81-90-3)
• EPA Substance Registry System: PHENOLPHTHALIN(81-90-3)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 81-90-3(Hazardous Substances Data)

Usage

Uses

Used in Chemical Analysis:
Phenolphthalein is used as a reagent for various chemical analyses, including the detection of oxidases, blood, hydrogen cyanide (HCN), peroxides, and copper. Its ability to change color in the presence of these substances makes it a valuable tool in laboratories.
Used in Material Science:
Phenolphthalein is used in the preparation method of polar polymer-doped nanoparticles and composite wave-absorbing materials containing dyes and metabolites. Its unique chemical properties allow it to enhance the performance of these materials, making them more effective in their respective applications.
Used in Dyes and Metabolite Analysis:
Phenolphthalein is used in the analysis of dyes and metabolites, where its ability to interact with these substances can provide valuable information about their properties and behavior. This can be particularly useful in fields such as environmental science, where understanding the behavior of dyes and metabolites is important for assessing the impact of pollutants.

InChI:InChI=1/C20H16O4/c21-15-9-5-13(6-10-15)19(14-7-11-16(22)12-8-14)17-3-1-2-4-18(17)20(23)24/h1-12,19,21-22H,(H,23,24)/p-1

Upstream product

• 85-44-9 phthalic anhydride 
• 108-95-2 phenol 
• 85-57-4 2-(4-hydroxy-benzoyl)-benzoic acid 
• 76-62-0 3,3-bis(3,5-dibromo-4-hydroxyphenyl)phthalide 
• 77-09-8 phenolphthalein 
• 7446-70-0 aluminium trichloride 
• 79-34-5 1,1,2,2-tetrachloroethane 
• 7664-93-9 sulfuric acid 
• 7647-01-0 hydrogenchloride 
• 21216-19-3 3,3-bis-(4-hydroxy-phenyl)-isoindolin-1-one-imine 
• 5449-84-3 phenolphthalein-4,4'-diyl diacetate 
• 6607-41-6 3,3-bis(4-hydroxyphenyl)-2-phenylisoindolin-1-one 
• 81-84-5 1,8-Naphthalic anhydride 
• 81-92-5 phenolphthalol 

Downstream Products

• 6315-80-6 3,3-bis(4-methoxyphenyl)-3H-isobenzofuran-1-one 
• 18846-84-9 2-[(4-hydroxy-phenyl)-(4-oxo-cyclohexa-2,5-dienylidene)-methyl]-benzoic acid methyl ester 
• 124119-41-1 3,3-bis-(4-isovaleryloxy-phenyl)-phthalide 
• 63450-78-2 ethyl 2-[bis(4-hydroxyphenyl)methyl]benzoate 
• 412020-47-4 2-hydroxy-5-[1-(4-hydroxy-phenyl)-3-oxo-phthalan-1-yl]-benzaldehyde 
• 518-51-4 phenolphthalein disodium salt 
• 81-92-5 phenolphthalol 
• 4081-02-1 4,4'-benzylidene-di-phenol 
• 118-79-6 2,4,6-tribromophenol 
• 5449-79-6 3,3-bis(4-chlorophenyl)-3H-isobenzofuran-1-one 
• 6607-42-7 3,3-bis(4-hydroxyphenyl)isoindolin-1-one 
• 21216-19-3 3,3-bis-(4-hydroxy-phenyl)-isoindolin-1-one-imine 
• 47252-88-0 1,1-Bis-(4-hydroxy-phenyl)-phthalan 
• 28818-25-9 2-(3,5,3',5'-tetrabromo-4,4'-dihydroxy-benzhydryl)-benzoic acid 

Relevant articles and documents

Preparation method of carboxylic acid compound

The invention provides a preparation method of a carboxylic acid compound. The preparation method comprises the following step of taking a lactone component to react with hydrogen in the presence of a compound catalyst to obtain the carboxylic acid compound. The compound catalyst comprises a hydrogenation catalyst and Lewis acid. In the presence of the compound catalyst comprising the hydrogenation catalyst and the Lewis acid, the lactone component is subjected to hydrogenation ring-opening reaction to obtain the carboxylic acid compound. The preparation method has the advantages of moderate reaction conditions and high yield; compared with a traditional method, less byproducts are generated, green and chemical requirements are met and the industrial value is better.

A Comprehensive Study on Metal Triflate-Promoted Hydrogenolysis of Lactones to Carboxylic Acids: From Synthetic and Mechanistic Perspectives

Direct hydrogenolysis of lactone to carboxylic acid (i.e., hydrogenolysis of the Calkoxy-O bond with the carbonyl group untouched) is generally difficult, as the current strategies employing Br?nsted acids as the catalyst usually require harsh conditions such as a high temperature and a high H2 pressure. Herein, we report a developed solvent-free catalytic transformation, in which W(OTf)6 is believed to promote the hydrogenolysis process. This strategy could efficiently hydrogenate lactones to carboxylic acids under extra mild conditions (e.g., a reaction temperature of 2) and showed a broad substrate scope. In addition, the catalytic protocol can be further applied to the hydrogenolysis of polyhydroxyalkanoate, as a renewable polymer, to the corresponding straight-chain carboxylic acids. An extensive mechanistic study was subsequently performed, and the density functional theory calculations revealed a reaction pattern, including the complete cleavage of the C=O bond with the assistance of the W(OTf)6 catalyst. Moreover, the key intermediate created in the mechanism, as an oxonium with an OTf moiety, was successfully detected by electrospray ionization mass spectra. Through a comparison with the Br?nsted acid-catalyzed system, the study confirmed that the existence of the OTf moiety can significantly lower the barriers associated with the rearrangement and elimination processes. Meanwhile, emphasis was placed on the critical role that the anion plays, as well as the fact that the anion effect is directly related to the chemoselectivity.

METHODS OF MANUFACTURE OF 2-ARYL-3,3-BIS(HYDROXYARYL)PHTHALIMIDINES

A synthetic route for producing a 2-phenyl-3,3-bis(4-hydroxyphenyl)phthalimidine, using a dihydrophenolphthalein intermediate is provided. The dihydrophenolphthalein can be obtained by reduction of a precursor phenolphthalein that is commonly used in the manufacture of phthalimidines. Formation of the dihydrophenolphthalein is followed by activation, amide formation, and oxidation to provide the product phthalimidine

Bisphenols and poly(imidoarylether ketone)s and poly(imidoarylether sulfone)s produced therefrom

Bisphenols having a pendent imide moiety, of formula (I) STR1 in which R1, R2, R3 and R4, which may be the same or different, are selected from hydrogen, fluorine, chlorine, bromine, alkyl of 1 to 6 carbon atoms, aryl of 6 to 10 carbon atoms, alkoxy of 1 to 6 carbon atoms and aryloxy of 6 to 10 carbon atoms; R5 is selected from fluorine, chlorine, bromine and alkyl of 1 to 6 carbon atoms, and m is 0, 1, 2, 3 or 4; and R7 is alkyl of 1 to 18 carbon atoms, aryl of 6 to 10 carbon atoms, unsubstituted or substituted one or more times by a substituent selected from fluorine, chlorine, trifluoromethyl, alkyl of 1 to 6 carbon atoms, and phenyl, or heteroaryl; are useful in producing poly(imidoarylether ketone)s and poly(imidoarylether sulfone)s which are amorphous and are soluble in readily available solvents, while displaying high glass transition temperatures and good thermo-oxidative stability.