- Synthesis method of 1-bromo-3-chlorodibenzofuran
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The invention belongs to the technical field of organic synthesis, and particularly discloses a novel synthesis method of 1-bromo-3-chlorodibenzofuran. According to the method, parachloroaniline is adopted as a raw material and firstly reacts with an N-bromosuccinimide (NBS) reagent to obtain a brominated product compound 2, then the compound 2 is subjected to a diazo-iodination reaction to obtain a compound 3, the compound 3 and o-methoxyphenylboronic acid are subjected to a suzuki coupling reaction to obtain a compound 4, methyl of the compound 4 is removed to obtain a compound 5, and finally, the compound 5 is subjected to intramolecular nucleophilic substitution reaction to obtain a final product. According to the method, cheap raw materials are used for replacing 4-chloro-2-fluoroaniline in the prior art, so that the production cost is greatly reduced; and the reaction yield of each step is high, the technological operation is simple, and the method is more suitable for industrial production.
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- Twelve-Step Asymmetric Synthesis of (-)-Nodulisporic Acid C
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A short, enantioselective synthesis of (-)-nodulisporic acid C is described. The route features two highly diastereoselective polycyclizations en route to the terpenoid core and the indenopyran fragment and a highly convergent assembly of a challenging indole moiety. Application of this chemistry allows for a 12-step synthesis of the target indoloterpenoid from commercially available material.
- Godfrey, Nicole A.,Schatz, Devon J.,Pronin, Sergey V.
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supporting information
p. 12770 - 12774
(2018/10/09)
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- Enantioposition-selective copper-catalyzed azide-alkyne cycloaddition for construction of chiral biaryl derivatives
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A highly enantioposition-selective copper-catalyzed azide-alkyne cycloaddition (CuAAC) of dialkynes bearing prochiral biaryls has been developed for the construction of 1,2,3-triazoles bearing axially chiral biaryl groups in up to 76% yield and up to 99% ee.
- Osako, Takao,Uozumi, Yasuhiro
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supporting information
p. 5866 - 5869
(2015/01/08)
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