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81074-81-9

5-(DIMETHYLAMINOMETHYL)FURFURYL ALCOHOL HYDROCHLORIDE, also known as Ranitidine EP Impurity F, is an organic compound that serves as a crucial intermediate in the synthesis of Ranitidine hydrochloride (R120000). This chemical plays a significant role in pharmaceutical manufacturing processes, contributing to the production of medications used for various therapeutic purposes.
Used in Pharmaceutical Industry:
5-(DIMETHYLAMINOMETHYL)FURFURYL ALCOHOL HYDROCHLORIDE is used as a chemical intermediate for the synthesis of Ranitidine hydrochloride (R120000), a medication primarily used for treating conditions like peptic ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome. Its role in the synthesis process is vital for creating an effective and widely prescribed medication to address gastrointestinal issues.

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  • 81074-81-9 Structure

  • Basic information

    1. Product Name: 5-(DIMETHYLAMINOMETHYL)FURFURYL ALCOHOL HYDROCHLORIDE
    2. Synonyms: 5-(dimethylaminomethyl)furfurylalcoholhydrochlo;LABOTEST-BB LT00159269;5-[(DIMETHYLAMINO)METHYL]-2-FURANMETHANOL HYDROCHLORIDE;5-(DIMETHYLAMINOMETHYL)-2-FURFURYL ALCOHOL HYDROCHLORIDE;5-(DIMETHYLAMINOMETHYL)FURFURYL ALCOHOL HYDROCHLORIDE;[[2-(hydroxymethyl)-5-furyl]methyl]ammonium chloride;[5-(dimethylaminomethyl)-2-furyl]methanol hydrochloride;5-(DIMETHYLAMINOMETHYL)FURFURYLALCOHOLHYDROCHLROIDE
    3. CAS NO:81074-81-9
    4. Molecular Formula: C8H13NO2*ClH
    5. Molecular Weight: 191.66
    6. EINECS: 279-686-0
    7. Product Categories: Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;Building Blocks;Furans;Heterocyclic Building Blocks;Heterocycles
    8. Mol File: 81074-81-9.mol

  • Chemical Properties

    1. Melting Point: 122-125 °C (dec.)(lit.)
    2. Boiling Point: 217.7°C at 760 mmHg
    3. Flash Point: 85.5°C
    4. Appearance: /
    5. Density: N/A
    6. Vapor Pressure: 0.0762mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
    9. Solubility: DMSO (Slightly), Methanol (Slightly)
    10. Stability: Hygroscopic
    11. BRN: 3703424
    12. CAS DataBase Reference: 5-(DIMETHYLAMINOMETHYL)FURFURYL ALCOHOL HYDROCHLORIDE(CAS DataBase Reference)
    13. NIST Chemistry Reference: 5-(DIMETHYLAMINOMETHYL)FURFURYL ALCOHOL HYDROCHLORIDE(81074-81-9)
    14. EPA Substance Registry System: 5-(DIMETHYLAMINOMETHYL)FURFURYL ALCOHOL HYDROCHLORIDE(81074-81-9)

  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26-36
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 81074-81-9(Hazardous Substances Data)

81074-81-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 81074-81-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,0,7 and 4 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 81074-81:
(7*8)+(6*1)+(5*0)+(4*7)+(3*4)+(2*8)+(1*1)=119
119 % 10 = 9
So 81074-81-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H13NO2.ClH/c1-9(2)5-7-3-4-8(6-10)11-7;/h3-4,10H,5-6H2,1-2H3;1H

81074-81-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Alfa Aesar

  • (L10934)  5-(Dimethylaminomethyl)furfuryl alcohol hydrochloride, 96%   

  • 81074-81-9

  • 5g

  • 303.0CNY

  • Detail

  • Alfa Aesar

  • (L10934)  5-(Dimethylaminomethyl)furfuryl alcohol hydrochloride, 96%   

  • 81074-81-9

  • 25g

  • 1359.0CNY

  • Detail

  • Aldrich

  • (411248)  5-(Dimethylaminomethyl)furfurylalcoholhydrochloride  98%

  • 81074-81-9

  • 411248-5G

  • 328.77CNY

  • Detail

81074-81-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name [5-[(dimethylamino)methyl]furan-2-yl]methanol,hydrochloride

1.2 Other means of identification

Product number -
Other names EINECS 279-686-0

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:81074-81-9 SDS

81074-81-9Upstream product

81074-81-9Relevant articles and documents

Method for production of amine compound

-

, (2008/06/13)

A method for the producing 2-[[[5-(dialkylamino)alkyl-2-furanyl]methyl]thio]-ethane amine by the reaction of cysteamine or cysteamine hydrochloride containing free hydrogen chloride with 5-(dialkyl amino)alkyl furfuryl alcohol, which method can be obtained the product in a highly yield by carrying out said reaction at a temperature in the range of 30° to 80° C.

Preparation, Characterisation, and Breakdown Products of Two Nitrosation Products of Ranitidine

Cholerton, Trevor J.,Clitherow, John,Hunt, John H.,Mackinnon, John W. M.,Martin-Smith, Michael,et al.

, p. 2818 - 2846 (2007/10/02)

Ranitidine, N--2-furanyl>methyl>thio>ethyl>-N'-methyl-2-nitro-1,1-ethenediamine, (1) reacts with one equivalent of nitrous acid to give N'--2-furanyl>methyl>thio>ethyl>-2-(hydroxyimino)-N-methyl-2-nitroethaneimidamide hydrochloride (2).In the presence of two equivalents of nitrous acid N'--2-furanyl>methyl>thio>ethyl>-2-(hydroxyimino)-N-methyl-2-nitro-N-nitrosoethanimidamide (8) is formed.In dilute hydrochloric acid the C,N-dinitrosated product (8) decomposes to give the C-mononitrosated product (2) which in turn decomposes to give 5--2-furanmethanol hydrochloride (3) and 5,6-dihydro-3-methylamino-2H-1,4-thiazine-2-one oxime hydrochloride (4).X-ray studies confirm the structure of the 1,4-thiazine-2-one oxime hydrochloride (4) and a U-shaped conformation of (8) in the solid.

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