- Method for synthesizing 2-methyl-1,2-propylene diamine
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The invention relates to a method for synthesizing 2-methyl-1,2-propylene diamine. According to the method, 2-amino-2-methyl-1-propyl alcohol is adopted as a raw material, and a cobalt catalyst and aids are combined to form a catalyst. The method has the advantages that the reaction pressure is low, the target product, namely the 2-methyl-1,2-propylene diamine, is high in selectivity, and the like, and relatively high industrial production values can be made.
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Paragraph 0011; 0012; 0014; 0016; 0018; 0020
(2018/06/04)
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- Novel preparation method of anagliptin intermediate 1,2-diamido-2-methylpropane
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The invention relates to a preparation method of an anagliptin intermediate 1,2-diamido-2-methylpropane (namely, a compound 1). Anagliptin is a DPP-IV inhibitor developed by the Sanwa Kagaku Kenkyusho Co, Ltd in Japan, and is mainly used for treating type-II diabetes mellitus; the compound 1 is an important intermediate for anagliptin synthesis. A structure of the compound 1 is represented in the specification.
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Paragraph 0007
(2016/12/16)
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- PROCESS FOR THE PREPARATION OF ALKYLDIAMINES
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Provided is a process for preparing alkyl diamine compounds in high purity. The process utilizes an alkyl amine compound during the reduction of a nitroamine, resulting in reduction of the concentration of undesired byproducts.
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Page/Page column 7
(2013/02/28)
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- PROCESS FOR THE PREPARATION OF 1,2-DIAMINES
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The invention relates to processes for the preparation of 1,2-diamines, and to the use of these compounds as intermediates for the preparation of several pharmaceutically active compounds. More particularly, it relates to the preparation of 2-methyl-1,2-diaminopropane. The process involves reductive cyclization of 1, 1 -cyanoanilide followed by hydrolysis of the resultant imidazole derivative to get 1,2-diamine.
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Page/Page column 8-9
(2008/06/13)
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- Method for producing 1,1-disubstituted ethylenediamine
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[PROBLEM TO BE SOLVED]: To provide a method for synthesizing 1,1-disubstituted ethylenediamine (III) safely and economically, and therefore making possible a industrial production. [SOLUTION]: The method for producing the intermediate shown by the general formula (II) characterized by reacting ketones shown by the general formula (I) , nitromethane and ammonia, next producing 1,1-disubstituted ethylenediamine shown by the general formula (III) by catalytic hydrogenation's reaction.(Wherein R1, R2 are at the same time or independently alkyl of C1-6, trifluoromethyl, or cycloalkyl of 3-10 formed by R1 and R2 and the carbon of the root.)
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Page/Page column 6
(2008/06/13)
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- SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS
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The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed
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- Preparation of ethylenediamine derivatives
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Described is a process for preparing 1,2-diaminoethane having the formula STR1 where R1, R2, R3, and R4 are each independently hydrogen, C1 -C20 alkyl, C3 -C12 cycloalkyl, C7 -C15 aralkyl, unsubstituted or substituted aryl or heteroaryl or alternatively, R1 and R2 together with the carbon atom form a 3 to 12 member cycloalkyl group, or with a heteroatom form a 3 to 12 member heterocyclic group and R3 and R4 together with the nitrogen atom form a 3 to 12 member heterocyclic group, optionally including oxygen, sulfur or phosphorus as a second heteroatom, the process comprising: reacting a preformed Schiff base with a nitroalkane as a neat mixture in the presence of a catalytic amount of an inorganic base to form the 1-nitro-2-aminoethane intermediate, which was then hydrogenated to give 1,2-diaminoethane.
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- Cosmetic composition containing an amide-amine type condensate, and a cosmetic treating process using said condensate
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A cosmetic composition for improving the suppleness of the skin or hair and for protecting the keratin of the skin or hair from degradation by atmospheric agents or light comprises in a cosmetic or dermatologic acceptable vehicle a saturated condensate resulting from the polyaddition of a bis-acrylamide and a sterically hindered primary diamine, the condensate being saturated by hydrogenation or by addition of a thiol or an amine on the double bonds of the acrylamide residue.
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- A NEW REDUCTIVE PROCEDURE FOR THE PREPARATION OF VICINAL DIAMINES AND MONOAMINES
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Selective reductive procedures for the preparation of vicinal diamines and monoamines from alkyl bromocyanamides are described.
- Jung, Sang-Hun,Kohn, Harold
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p. 399 - 402
(2007/10/02)
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- Optical Resolution and Circular Dichroism Spectra of Mixed-diamine Palladium(II) Complexes with Configurational Chirality
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Six square-planar complexes, (ClO4)2 (meso-stien = meso-1,2-diphenyl-1,2-ethanediamine; L = N,N-diethylethylenediamine, N,N-dimethylethylenediamine, 2-methyl-1,2-propanediamine, N2,N2-dimethyl-2-methyl-1,2-propanediamine, N,N-dimethyl-1,3-propenediamine, and (2S)-N1,N1-diethyl-1,2-propanediamine), were prepared and optically resolved (or separated in the case of the last named ligand) using diacetyl-d-tartaric anhydride as the resolving agent.Their electronic absorption and CD spectra were measured.A definite additivity has been confirmed between the configurational CD caused by the chiral configuration and the vicinal CD due to the asymmetric carbon atom in the (2S)-N1,N1-diethyl-1,2-propanediamine complex.Absolute configurations of this and the other five complexes have been assigned by examining molecular models and the CD spectra.
- Nakayama, Kazuhiko,Komorita, Takashi,Shimura, Yoichi
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p. 1056 - 1062
(2007/10/02)
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