811464-25-2

Basic information

• Product Name: 5-BroMo-2-(1H-pyrazol-3-yl)pyridine
• Synonyms: 5-BroMo-2-(1H-pyrazol-3-yl)pyridine;5-bromo-2-(1H-pyrazol-5-yl)pyridine
• CAS NO: 811464-25-2
• Molecular Formula: C₈H₆BrN₃
• Molecular Weight: 224.05734
• Mol File: 811464-25-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-BroMo-2-(1H-pyrazol-3-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BroMo-2-(1H-pyrazol-3-yl)pyridine(811464-25-2)
• EPA Substance Registry System: 5-BroMo-2-(1H-pyrazol-3-yl)pyridine(811464-25-2)

Safety Data

• Hazardous Substances Data: 811464-25-2(Hazardous Substances Data)

Usage

Uses

Used in Research and Pharmaceutical Applications:
5-Bromo-2-(1H-pyrazol-3-yl)pyridine is used as a building block in the synthesis of various organic compounds for research and pharmaceutical purposes. Its unique structure allows for the development of new compounds with potential therapeutic properties.
Used in Kinase Inhibition Studies:
5-Bromo-2-(1H-pyrazol-3-yl)pyridine is used as a kinase inhibitor in biological research. Its potential role in inhibiting kinase activity makes it a valuable tool for studying the effects of kinase inhibition on cellular processes and the development of targeted therapies.
Used in Drug Development:
5-Bromo-2-(1H-pyrazol-3-yl)pyridine is used in the development of new drugs. Its potential biological activities and unique chemical structure make it a promising candidate for the creation of novel therapeutic agents.
Used in Agrochemical Development:
5-Bromo-2-(1H-pyrazol-3-yl)pyridine may have applications in the development of new agrochemicals. Its potential use in this field could lead to the creation of innovative products for agricultural and pest control purposes.

Upstream product

• 214701-49-2 1-(5-bromopyridin-2-yl)ethanone 
• 97483-77-7 2-Cyano-5-bromopyridine 
• 624-28-2 2,5-dibromopyridine 
• 811464-24-1 (E)-1-(5-Bromo-pyridin-2-yl)-3-dimethylamino-propenone 

Downstream Products

• 811464-20-7 5-bromo-2-(1-methyl-1H-pyrazol-3-yl)pyridine 

Relevant articles and documents

PYRAZOLE DERIVATIVES AS THAT MODULATE THE ACTIVITY OF CDK, GSK AND AURORA KINASES

The invention provides a compound of the formula (I): for use in medicine: or salts or tautomers or N-oxides or solvates thereof; wherein R1 is an optionally substituted heterocyclic group having from 3 to 12 ring members provided that the cyclic group joined to the pyrazole contains at least one heteroatom selected from N, O or S; A is a bond or -Y-(B)n-; B is C=O, NRg(C=O) or O(C=O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; n is 0 or 1; Y is a bond or an alkylene chain of 1,2 or 3 carbon atoms in length; R2 is hydrogen; halogen; C1-4 alkoxy (e.g. methoxy); or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy); R3 is selected from optionally substituted carbocyclic and heterocyclic groups having from 3 to 12 ring members or an optionally substituted C1-8 hydrocarbyl group; with the proviso that R1 is not formula (II): where X, R3’ and R4’ are defined in the claims.

Synthesis and antibacterial activity of oxazolidinones containing pyridine substituted with heteroaromatic ring

Oxazolidinone derivatives containing pyridine substituted with heteroaromatic ring were synthesized and exhibited potent in vitro and in vivo antibacterial activities against many antibiotic-resistant microbial strains. A series of oxazolidinone derivatives, which morpholino group of linezolid was replaced with heteroaromatic ring substituted pyridine moiety, were newly synthesized, and their substituted effects on in vitro and in vivo antibacterial activities were evaluated against four problematic gram-positive strains including drug resistant strains and two gram-negative strains. Most compounds exhibited the enhanced in vitro activities with 4-16-fold and three compounds exerted more than 2-fold increased in vivo efficacies than linezolid.