811784-21-1

Basic information

• Product Name: Furan, 2-[1-(4-methoxyphenyl)ethyl]-5-methyl- (9CI)
• Synonyms: Furan, 2-[1-(4-methoxyphenyl)ethyl]-5-methyl- (9CI)
• CAS NO: 811784-21-1
• Molecular Formula: C₁₄H₁₆O₂
• Molecular Weight: 216.27564
• Product Categories: METHYL
• Mol File: 811784-21-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Furan, 2-[1-(4-methoxyphenyl)ethyl]-5-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Furan, 2-[1-(4-methoxyphenyl)ethyl]-5-methyl- (9CI)(811784-21-1)
• EPA Substance Registry System: Furan, 2-[1-(4-methoxyphenyl)ethyl]-5-methyl- (9CI)(811784-21-1)

Safety Data

• Hazardous Substances Data: 811784-21-1(Hazardous Substances Data)

Upstream product

• 534-22-5 2-methylfuran 
• 1538-89-2 1-(1-chloro-ethyl)-4-methoxy-benzene 
• 3319-15-1 rac-1-(4-methoxyphenyl)-ethanol 

Downstream Products

• 942-54-1 2-(4-methoxyphenyl)propanoic acid 

Relevant articles and documents

A novel synthetic route to 2-arylalkanoic acids by a ruthenium-catalyzed chemoselective oxidation of furan rings

An efficient two-step synthesis of 2-arylalkanoic acids from 1-arylalkanols is described. Firstly, 1-arylalkylfuran derivatives were synthesized in high yields by the metal triflate catalyzed Friedel-Crafts alkylation of 2-methylfuran with 1-arylalkanols without employing anhydrous conditions. The chemoselective oxidation of the furan ring in 1-arylalkylfurans to carboxylic acid was then investigated. In a solvent system of hexane-EtOAc/H2O (1:3:4), the furan ring was selectively oxidized with 7 equivalents of NaIO 4 by using 0.5 mol% RuCl3 as catalyst to give 2-arylalkanoic acids in good yields. The selectivity of ruthenium oxidation was controlled by the solvent ratio of hexane-EtOAc. Georg Thieme Verlag Stuttgart.

Br?nsted-acid-catalyzed coupling of electron-rich arenes with substituted allylic and secondary benzylic alcohols

p-Toluenesulfonic acid and triflic acid catalyze efficiently the coupling of electron-rich arenes with allylic and benzylic alcohols. Reactions are conducted under mild conditions, in air, and in the absence of solvent.

METHOD FOR ESTABLISHING CC BONDS BETWEEN ELECTROPHILIC SUBSTRATES AND ? - NUCLEOPHILES IN NEUTRAL TO ALKALINE AQUEOUS OR ALCOHOLIC SOLVENTS WITHOUT USING A LEWIS OR BRONSTED ACID

The invention relates to a method for establishing carbon-carbon bonds by reacting electropohilic substrates that have a solvolysis rate kEtOH (25°C) > 10-6 s-1 and ? compounds. The method is characterized by generating the intermediary carbocations in neutral to alkaline aqueous or alcoholic solvents or solvent mixtures without using a Lewis or Br?nsted acid.

Electrophilic alkylations in neutral aqueous or alcoholic solutions

Acid-free Friedel-Crafts chemistry: A paradox? Nucleophilicity scales, based on reactions with benzhydrylium ions, show that many π systems are more nucleophilic than aqueous or alcoholic solutions that are generally employed as solvents for SN1 reactions. Solvolytically generated carbocations can, therefore, be trapped by donor-substituted arenes and alkenes to form products of Friedel-Crafts-type reactions in neutral aqueous solutions (see scheme).